Interactor 1: SESN2 (P58004)
Sestrin-2 (EC 1.11.1.-) (Hypoxia-induced gene)
Gene: SESN2
Interactor 2: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2
Species: Homo sapiens
Source: biogrid
Category: High-throughput
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.38 | 0.55 | 0.460 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 21988832 |
| Identification Methods | two hybrid |
| Interaction Type | direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0030330 - DNA damage response, signal transduction by p53 class mediator |
| Homologous interactions | 0 |
Service provided by Combinatics, Japan
Last updated: 11Aug2025
