HitPredict

Interactor 1: DLK1 (P80370)
Protein delta homolog 1 (DLK-1) (pG2) [Cleaved into: Fetal antigen 1 (FA1)]
Gene: DLK1

Interactor 2: UBE3B (Q7Z3V4)
Ubiquitin-protein ligase E3B (EC 2.3.2.26) (HECT-type ubiquitin transferase E3B)
Gene: UBE3B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.50	0.609

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 383 Hs			1 1068
+	Hs
		804164 NOTC1_HUMAN (6-314): 3.86e-22: 100: 22.02		NEDD4_HUMAN (604-1066): 1.95e-158: 505: 28.54
+	Dm
		247208 TENM_DROME (164-354): 9.9e-24: 105: 12.92		NEDD4_DROME (550-1065): 2.41e-159: 499: 27.24
+	Hs
		804318 NOTC1_HUMAN (6-314): 3.86e-22: 100: 22.02		ITCH_HUMAN (604-1066): 1.43e-161: 502: 28.02
+	Hs
		804323 NOTC1_HUMAN (6-314): 3.86e-22: 100: 22.02		NED4L_HUMAN (604-1066): 8.92e-159: 497: 27.68
+	Dm
		422918 NOTCH_DROME (132-340): 2.73e-17: 85.9: 23.36		NEDD4_DROME (550-1065): 2.41e-159: 499: 27.24
+	Hs
		804337 NOTC1_HUMAN (6-314): 3.86e-22: 100: 22.02		WWP1_HUMAN (615-1066): 2.37e-153: 481: 26.71
+	Hs
		944125 JAG1_HUMAN (114-345): 5.39e-15: 79: 14.68		ITCH_HUMAN (604-1066): 1.43e-161: 502: 28.02
+	Hs
		125785 NOTC3_HUMAN (22-244): 1.94e-17: 86.7: 31.37		WWP2_HUMAN (655-1066): 5.73e-159: 494: 29.30
+	Dm
		422970 NOTCH_DROME (132-340): 2.73e-17: 85.9: 23.36		SUDX_DROME (654-1065): 2.13e-153: 482: 29.78
+	Mm
		966330 NOTC1_MOUSE (6-274): 3.7e-10: 64: 18.13		ITCH_MOUSE (604-1066): 2.87e-161: 500: 27.80
+	Dm
		247320 TENM_DROME (164-354): 9.9e-24: 105: 12.92		Q9W325_DROME (645-1067): 1.52e-140: 431: 29.81