HitPredict

Interactor 1: S10AC (P80511)
Protein S100-A12 (CGRP) (Calcium-binding protein in amniotic fluid 1) (CAAF1) (Calgranulin-C) (CAGC) (Extracellular newly identified RAGE-binding protein) (EN-RAGE) (Migration inhibitory factor-related protein 6) (MRP-6) (p6) (Neutrophil S100 protein) (S100 calcium-binding protein A12) [Cleaved into: Calcitermin]
Gene: S100A12

Interactor 2: S10AC (P80511)
Protein S100-A12 (CGRP) (Calcium-binding protein in amniotic fluid 1) (CAAF1) (Calgranulin-C) (CAGC) (Extracellular newly identified RAGE-binding protein) (EN-RAGE) (Migration inhibitory factor-related protein 6) (MRP-6) (p6) (Neutrophil S100 protein) (S100 calcium-binding protein A12) [Cleaved into: Calcitermin]
Gene: S100A12

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.70 1.00 0.839

The method score is based on:

Property Details
Experiments 11134923, 10976885, 19386136
Identification Methods x-ray crystallography, mass spectrometry studies of complexes, molecular sieving, detection by mass spectrometry
Interaction Type association, physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains S_100~S_100
Common GO terms GO:0002548 - monocyte chemotaxis
GO:0005507 - copper ion binding
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
and 23 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 92
Hs

1 92
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024