HitPredict

Interactor 1: S10AC (P80511)
Protein S100-A12 (CGRP) (Calcium-binding protein in amniotic fluid 1) (CAAF1) (Calgranulin-C) (CAGC) (Extracellular newly identified RAGE-binding protein) (EN-RAGE) (Migration inhibitory factor-related protein 6) (MRP-6) (p6) (Neutrophil S100 protein) (S100 calcium-binding protein A12) [Cleaved into: Calcitermin]
Gene: S100A12

Interactor 2: RAGE (Q15109)
Advanced glycosylation end product-specific receptor (Receptor for advanced glycosylation end products)
Gene: AGER

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	19727205, 19386136
Identification Methods	solid phase assay, surface plasmon resonance
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	C2-set_2~S_100, Ig_3~S_100
Common GO terms	GO:0005576 - extracellular region GO:0005886 - plasma membrane GO:0006954 - inflammatory response GO:0051092 - positive regulation of NF-kappaB transcription factor activity
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 92 Hs			1 404
+	Rn
		385826 S100B_RAT (1-92): 1.25e-29: 102: 36.96		RAGE_RAT (1-404): 1.03e-73: 237: 77.97
+	Hs
		638960 S100P_HUMAN (1-91): 4.22e-34: 114: 45.06		RAGE_HUMAN (1-404): 8.32e-69: 224: 100.00
+	Hs
		615216 S10A1_HUMAN (2-91): 2.44e-33: 112: 37.78		RAGE_HUMAN (1-404): 8.32e-69: 224: 100.00
+	Hs
		380779 S100B_HUMAN (1-92): 3.09e-30: 104: 38.04		RAGE_HUMAN (1-404): 8.32e-69: 224: 100.00
+	Hs
		642944 S10A4_HUMAN (3-90): 2.12e-30: 104: 34.09		RAGE_HUMAN (1-404): 8.32e-69: 224: 100.00
+	Hs
		793247 S10AA_HUMAN (2-89): 1.9e-29: 102: 31.82		MUC18_HUMAN (22-301): 1.39e-58: 203: 24.92
+	Hs
		639033 S100P_HUMAN (1-91): 4.22e-34: 114: 45.06		PXDN_HUMAN (172-403): 7.12e-25: 109: 13.42
+	Hs
		642975 S10A4_HUMAN (3-90): 2.12e-30: 104: 34.09		PXDN_HUMAN (172-403): 7.12e-25: 109: 13.42
+	Hs
		661374 S10A2_HUMAN (2-90): 1.46e-29: 102: 35.96		PXDN_HUMAN (172-403): 7.12e-25: 109: 13.42