HitPredict

Interactor 1: EREP3 (P81408)
Protein ENTREP3 (Endosomal transmembrane epsin interactor 3) (Protein COTE1)
Gene: ENTREP3

Interactor 2: HERC3 (Q15034)
Probable E3 ubiquitin-protein ligase HERC3 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 3) (HECT-type E3 ubiquitin transferase HERC3)
Gene: HERC3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.50	0.558

Property	Details
Experiments	26186194, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 668 Hs			1 1050
+	Hs
		946398 EREP3_HUMAN (1-668): 0: 1058: 100.00		HERC4_HUMAN (1-1049): 0: 1067: 55.72
+	Hs
		946429 EREP3_HUMAN (1-668): 0: 1058: 100.00		ITCH_HUMAN (604-1048): 8.2e-178: 544: 26.60
+	Hs
		946437 EREP3_HUMAN (1-668): 0: 1058: 100.00		WWP1_HUMAN (605-1048): 6.26e-173: 532: 24.09
+	Hs
		808086 EREP3_HUMAN (1-668): 0: 1058: 100.00		NEDD4_HUMAN (604-1048): 8.67e-167: 527: 24.22
+	Hs
		946430 EREP3_HUMAN (1-668): 0: 1058: 100.00		NED4L_HUMAN (606-1048): 2.42e-169: 524: 25.21
+	Hs
		1065035 EREP1_HUMAN (111-367): 3.33e-88: 284: 23.91		HERC3_HUMAN (1-1050): 0: 1145: 100.00
+	Hs
		946449 EREP3_HUMAN (1-668): 0: 1058: 100.00		HECW2_HUMAN (702-1049): 6.6e-48: 189: 32.14
+	Hs
		1079771 EREP1_HUMAN (111-367): 3.33e-88: 284: 23.91		ITCH_HUMAN (604-1048): 8.2e-178: 544: 26.60
+	Hs
		125488 EREP1_HUMAN (111-367): 3.33e-88: 284: 23.91		WWP2_HUMAN (573-1048): 1.25e-175: 537: 23.06
+	Hs
		1079783 EREP1_HUMAN (111-367): 3.33e-88: 284: 23.91		WWP1_HUMAN (605-1048): 6.26e-173: 532: 24.09
+	Hs
		808136 EREP1_HUMAN (111-367): 3.33e-88: 284: 23.91		NEDD4_HUMAN (604-1048): 8.67e-167: 527: 24.22
+	Hs
		1079773 EREP1_HUMAN (111-367): 3.33e-88: 284: 23.91		NED4L_HUMAN (606-1048): 2.42e-169: 524: 25.21
+	Hs
		125597 Q8WU02_HUMAN (267-419): 3.85e-48: 168: 23.08		WWP2_HUMAN (573-1048): 1.25e-175: 537: 23.06
+	Hs
		1259694 Q8WU02_HUMAN (267-419): 3.85e-48: 168: 23.08		WWP1_HUMAN (605-1048): 6.26e-173: 532: 24.09
+	Hs
		1079795 EREP1_HUMAN (111-367): 3.33e-88: 284: 23.91		HECW2_HUMAN (702-1049): 6.6e-48: 189: 32.14