Interactor 1: HTRA4 (P83105)
Serine protease HTRA4 (EC 3.4.21.-) (High-temperature requirement factor A4)
Gene: HTRA4

Interactor 2: HTRA4 (P83105)
Serine protease HTRA4 (EC 3.4.21.-) (High-temperature requirement factor A4)
Gene: HTRA4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.70 1.00 0.840

The method score is based on:

Property Details
Experiments 25002585, 31036715, 31470122
Identification Methods protease assay, molecular sieving
Interaction Type protein cleavage, physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains IGFBP~Kazal_2, Kazal_2~Kazal_2, PDZ_2~PDZ_2, PDZ_2~Trypsin_2, Trypsin_2~Trypsin_2
Common GO terms GO:0004175 - endopeptidase activity
GO:0004252 - serine-type endopeptidase activity
GO:0005576 - extracellular region
GO:0006508 - proteolysis
GO:0012501 - programmed cell death
and 2 others

more...

Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 476
Hs

1 476
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Ss
+ At
+ Ec
+ Ec
+ Ec
+ Sp
+ Hs
+ Dr
+ Sp
+ At

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024