Interactor 1: HTRA4 (P83105)
Serine protease HTRA4 (EC 3.4.21.-) (High-temperature requirement factor A4)
Gene: HTRA4
Interactor 2: HTRA3 (P83110)
Serine protease HTRA3 (EC 3.4.21.-) (High-temperature requirement factor A3) (Pregnancy-related serine protease)
Gene: HTRA3
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.52 | 1.00 | 0.724 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25002585 |
| Identification Methods | anti tag coimmunoprecipitation, protease assay |
| Interaction Type | physical association, protein cleavage |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | IGFBP~Kazal_2, Kazal_2~Kazal_2, PDZ_2~PDZ_6, PDZ_2~Trypsin_2, PDZ_6~Trypsin_2, Trypsin_2~Trypsin_2 |
| Common GO terms | GO:0004175 - endopeptidase activity GO:0004252 - serine-type endopeptidase activity GO:0005576 - extracellular region GO:0006508 - proteolysis GO:0030512 - negative regulation of transforming growth factor beta receptor signaling pathway |
| Homologous interactions | 15 |
Homologous interactions
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
