HitPredict

Interactor 1: TNIK (P83510)
Traf2 and NCK-interacting protein kinase (EC 2.7.11.1)
Gene: TNIK

Interactor 2: GIT1 (Q68FF6)
ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1)
Gene: GIT1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	28671696
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~Pkinase
Common GO terms	GO:0098978 - glutamatergic synapse
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1323 Mm			1 770
+	Mm
		949275 TNIK_MOUSE (1-1323): 0: 1277: 100.00		AGAP2_MOUSE (2-224): 1.16e-46: 181: 29.15
+	Hs
		1231760 TNIK_HUMAN (1-1323): 0: 1245: 95.15		AN36B_HUMAN (114-766): 1.92e-50: 193: 12.13
+	Mm
		103596 TNIK_MOUSE (1-1323): 0: 1277: 100.00		ANK3_MOUSE (60-565): 6.42e-37: 152: 12.73
+	Mm
		949370 TNIK_MOUSE (1-1323): 0: 1277: 100.00		ANK2_MOUSE (89-573): 7.21e-30: 129: 11.89
+	Hs
		1021472 TNIK_HUMAN (1-1323): 0: 1245: 95.15		ANK3_HUMAN (174-528): 8.05e-33: 139: 10.36
+	Mm
		90327 E0CZD7_MOUSE (1-1323): 0: 1198: 91.96		AGAP2_MOUSE (2-224): 1.16e-46: 181: 29.15
+	Hs
		965172 TNIK_HUMAN (1-1323): 0: 1245: 95.15		ANK2_HUMAN (89-573): 7.15e-31: 133: 11.72
+	Hs
		1335966 TNIK_HUMAN (1-1323): 0: 1245: 95.15		TANC2_HUMAN (179-479): 2.76e-15: 82.6: 11.18
+	Hs
		1356406 TNIK_HUMAN (1-1323): 0: 1245: 95.15		ANR50_HUMAN (213-528): 8.62e-15: 81: 10.94
+	Mm
		1112654 MINK1_MOUSE (1-1323): 0: 1095: 64.51		AGAP2_MOUSE (2-224): 1.16e-46: 181: 29.15
+	Hs
		324887 M4K4_HUMAN (1-1323): 0: 1016: 62.17		TANC2_HUMAN (179-479): 2.76e-15: 82.6: 11.18
+	Mm
		100217 F7AMS7_MOUSE (148-1323): 0: 898: 59.89		AGAP2_MOUSE (2-224): 1.16e-46: 181: 29.15
+	Hs
		681853 AKT1_HUMAN (3-358): 1.62e-122: 390: 21.08		ACAP1_HUMAN (2-306): 2.22e-53: 199: 23.39
+	Dm
		1249831 HIPPO_DROME (1-317): 6.16e-109: 360: 38.89		GIT_DROME (9-642): 1.35e-63: 228: 33.52
+	Hs
		681996 AKT1_HUMAN (3-358): 1.62e-122: 390: 21.08		AGAP2_HUMAN (2-224): 4.77e-49: 189: 31.86