HitPredict

Interactor 1: CBX1 (P83916)
Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta)
Gene: CBX1

Interactor 2: H31T (Q16695)
Histone H3.1t (H3/t) (H3t) (H3/g) (Histone H3.4)
Gene: H3-4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.664

Property	Details
Experiments	20850016, 21047797, 22606318, 21888893
Identification Methods	unspecified method, affinity chromatography technology, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006325 - chromatin organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 185 Hs			1 136
+	Hs
		934721 CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49		H31_HUMAN (1-136): 6.88e-62: 187: 97.06
+	Hs
		1027017 CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49		H31T_HUMAN (1-136): 2.65e-61: 186: 100.00
+	Hs
		934657 CBX1_HUMAN (1-185): 2.21e-62: 193: 100.00		H31_HUMAN (1-136): 6.88e-62: 187: 97.06
+	Mm
		935445 CBX1_MOUSE (1-185): 2.21e-62: 193: 100.00		H31_MOUSE (1-136): 6.88e-62: 187: 97.06
+	Hs
		952310 CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49		H33_HUMAN (1-136): 4.53e-61: 185: 93.38
+	Mm
		952771 Q9DCC5_MOUSE (1-177): 2.11e-63: 195: 69.49		H33_MOUSE (1-136): 4.53e-61: 185: 93.38
+	Hs
		1027078 CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49		H32_HUMAN (1-136): 1.34e-60: 184: 96.32
+	Mm
		952270 Q9DCC5_MOUSE (1-177): 2.11e-63: 195: 69.49		H32_MOUSE (1-136): 1.34e-60: 184: 96.32
+	Hs
		949755 CBX1_HUMAN (1-185): 2.21e-62: 193: 100.00		H33_HUMAN (1-136): 4.53e-61: 185: 93.38
+	Hs
		949821 CBX1_HUMAN (1-185): 2.21e-62: 193: 100.00		H32_HUMAN (1-136): 1.34e-60: 184: 96.32
+	Mm
		949929 CBX1_MOUSE (1-185): 2.21e-62: 193: 100.00		H32_MOUSE (1-136): 1.34e-60: 184: 96.32
+	Hs
		800341 CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45		H31_HUMAN (1-136): 6.88e-62: 187: 97.06
+	Hs
		800397 CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45		H31T_HUMAN (1-136): 2.65e-61: 186: 100.00
+	Hs
		800347 CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45		H33_HUMAN (1-136): 4.53e-61: 185: 93.38
+	Mm
		952749 CBX5_MOUSE (1-183): 7.63e-60: 186: 57.98		H33_MOUSE (1-136): 4.53e-61: 185: 93.38
+	Hs
		800434 CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45		H32_HUMAN (1-136): 1.34e-60: 184: 96.32
+	Mm
		952259 CBX5_MOUSE (1-183): 7.63e-60: 186: 57.98		H32_MOUSE (1-136): 1.34e-60: 184: 96.32
+	Dm
		356124 Q9W396_DROME (20-185): 1.25e-58: 185: 52.41		H3_DROME (1-136): 1.34e-60: 184: 96.32
+	Hs
		828217 CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49		CENPA_HUMAN (9-133): 3.54e-44: 142: 49.24
+	Hs
		800317 CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45		CENPA_HUMAN (9-133): 3.54e-44: 142: 49.24