HitPredict

Interactor 1: CBX1 (P83916)
Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta)
Gene: CBX1

Interactor 2: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 185 Hs			1 126
+	Hs
		1027018 CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		420833 CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49		H2B1J_HUMAN (1-126): 7.8e-54: 166: 99.21
+	Hs
		918334 CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		241519 CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Hs
		420825 CBX1_HUMAN (1-185): 2.21e-62: 193: 100.00		H2B1J_HUMAN (1-126): 7.8e-54: 166: 99.21
+	Hs
		918291 CBX1_HUMAN (1-185): 2.21e-62: 193: 100.00		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		707585 CBX1_HUMAN (1-185): 2.21e-62: 193: 100.00		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Mm
		1145436 Q9DCC5_MOUSE (1-177): 2.11e-63: 195: 69.49		H2B1B_MOUSE (1-126): 4.91e-52: 162: 96.03
+	Mm
		949938 CBX1_MOUSE (1-185): 2.21e-62: 193: 100.00		H2B1B_MOUSE (1-126): 4.91e-52: 162: 96.03
+	Hs
		800336 CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		800398 CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		241469 CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Mm
		1143022 CBX5_MOUSE (1-183): 7.63e-60: 186: 57.98		H2B1B_MOUSE (1-126): 4.91e-52: 162: 96.03
+	Hs
		800460 CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45		H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03
+	Hs
		203602 SUV91_HUMAN (13-121): 4.22e-29: 112: 21.10		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Hs
		1087494 CDYL_HUMAN (7-120): 2.53e-25: 103: 25.86		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		918778 CDYL_HUMAN (7-120): 2.53e-25: 103: 25.86		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		315974 CBX6_HUMAN (12-101): 1.25e-25: 103: 30.00		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		1231263 CDYL_HUMAN (7-120): 2.53e-25: 103: 25.86		H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03
+	Hs
		1282983 CDYL_HUMAN (7-120): 2.53e-25: 103: 25.86		H2B1A_HUMAN (1-126): 3.43e-46: 147: 85.04