HitPredict

Interactor 1: CBX1 (P83917)
Chromobox protein homolog 1 (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein)
Gene: CBX1

Interactor 2: H32 (P84228)
Histone H3.2 (H3-clustered histone 13) (H3-clustered histone 14) (H3-clustered histone 15) (H3-clustered histone 2) (H3-clustered histone 3) (H3-clustered histone 4) (H3-clustered histone 6) (H3-clustered histone 7)
Gene: H3c2

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29795351
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0006325 - chromatin organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 185 Mm			1 136
+	Hs
		934721 CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Hs
		1027017 CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49		H31T_HUMAN (1-136): 8.3e-62: 187: 96.32
+	Hs
		934657 CBX1_HUMAN (1-185): 2.21e-62: 193: 100.00		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Mm
		935445 CBX1_MOUSE (1-185): 2.21e-62: 193: 100.00		H31_MOUSE (1-136): 1.98e-62: 189: 99.27
+	Hs
		1027078 CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49		H32_HUMAN (1-136): 3.73e-61: 186: 100.00
+	Mm
		952270 Q9DCC5_MOUSE (1-177): 2.11e-63: 195: 69.49		H32_MOUSE (1-136): 3.73e-61: 186: 100.00
+	Hs
		952310 CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49		H33_HUMAN (1-136): 1.59e-61: 186: 97.06
+	Mm
		952771 Q9DCC5_MOUSE (1-177): 2.11e-63: 195: 69.49		H33_MOUSE (1-136): 1.59e-61: 186: 97.06
+	Hs
		949795 CBX1_HUMAN (1-185): 2.21e-62: 193: 100.00		H31T_HUMAN (1-136): 8.3e-62: 187: 96.32
+	Hs
		949755 CBX1_HUMAN (1-185): 2.21e-62: 193: 100.00		H33_HUMAN (1-136): 1.59e-61: 186: 97.06
+	Hs
		949821 CBX1_HUMAN (1-185): 2.21e-62: 193: 100.00		H32_HUMAN (1-136): 3.73e-61: 186: 100.00
+	Hs
		800341 CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Hs
		800397 CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45		H31T_HUMAN (1-136): 8.3e-62: 187: 96.32
+	Hs
		800347 CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45		H33_HUMAN (1-136): 1.59e-61: 186: 97.06
+	Hs
		800434 CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45		H32_HUMAN (1-136): 3.73e-61: 186: 100.00
+	Mm
		952259 CBX5_MOUSE (1-183): 7.63e-60: 186: 57.98		H32_MOUSE (1-136): 3.73e-61: 186: 100.00
+	Mm
		952749 CBX5_MOUSE (1-183): 7.63e-60: 186: 57.98		H33_MOUSE (1-136): 1.59e-61: 186: 97.06
+	Dm
		356124 Q9W396_DROME (20-185): 1.25e-58: 185: 52.41		H3_DROME (1-136): 3.73e-61: 186: 100.00
+	Hs
		828217 CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49		CENPA_HUMAN (9-133): 2.85e-44: 143: 50.00
+	Hs
		800317 CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45		CENPA_HUMAN (9-133): 2.85e-44: 143: 50.00