HitPredict

Interactor 1: SMAD3 (P84022)
Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)
Gene: SMAD3

Interactor 2: MED15 (Q96RN5)
Mediator of RNA polymerase II transcription subunit 15 (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a) (Mediator complex subunit 15) (Positive cofactor 2 glutamine/Q-rich-associated protein) (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Trinucleotide repeat-containing gene 7 protein)
Gene: MED15

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	12167862
Identification Methods	affinity chromatography technology, coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 425 Hs			1 788
+	Hs
		1078631 SMAD2_HUMAN (1-425): 0: 589: 83.73		MED15_HUMAN (1-788): 2.62e-102: 335: 100.00
+	Xl
		1155783 Q90YE5_XENLA (1-425): 0: 613: 95.54		MED15_XENLA (7-788): 3.35e-93: 310: 63.04
+	Xl
		1153625 Q6IRR4_XENLA (1-425): 0: 589: 83.94		MED15_XENLA (7-788): 3.35e-93: 310: 63.04
+	Hs
		1078747 SMAD1_HUMAN (1-425): 0: 559: 60.09		MED15_HUMAN (1-788): 2.62e-102: 335: 100.00
+	Dm
		785517 MAD_DROME (1-425): 0: 571: 61.09		MED15_DROME (9-784): 1.39e-55: 206: 24.72
+	Hs
		159959 SMAD3_HUMAN (1-425): 0: 636: 100.00		HGS_HUMAN (71-479): 3.22e-23: 107: 18.08
+	Hs
		950234 SMAD3_HUMAN (1-425): 0: 636: 100.00		CBP_HUMAN (139-583): 4.11e-10: 65.9: 11.24
+	Xl
		1155784 Q9W639_XENLA (23-414): 3.81e-131: 390: 35.71		MED15_XENLA (7-788): 3.35e-93: 310: 63.04
+	Hs
		160010 SMAD2_HUMAN (1-425): 0: 589: 83.73		HGS_HUMAN (71-479): 3.22e-23: 107: 18.08
+	Hs
		1035561 SMAD4_HUMAN (23-414): 1.55e-117: 355: 33.21		MED15_HUMAN (1-788): 2.62e-102: 335: 100.00
+	Hs
		160011 SMAD1_HUMAN (1-425): 0: 559: 60.09		HGS_HUMAN (71-479): 3.22e-23: 107: 18.08
+	Hs
		160166 SMAD5_HUMAN (1-425): 0: 556: 59.83		HGS_HUMAN (71-479): 3.22e-23: 107: 18.08
+	Hs
		1078605 SMAD2_HUMAN (1-425): 0: 589: 83.73		CBP_HUMAN (139-583): 4.11e-10: 65.9: 11.24
+	Hs
		1078735 SMAD1_HUMAN (1-425): 0: 559: 60.09		CBP_HUMAN (139-583): 4.11e-10: 65.9: 11.24
+	Hs
		159987 SMAD4_HUMAN (23-414): 1.55e-117: 355: 33.21		HGS_HUMAN (71-479): 3.22e-23: 107: 18.08
+	Hs
		1035526 SMAD4_HUMAN (23-414): 1.55e-117: 355: 33.21		CBP_HUMAN (139-583): 4.11e-10: 65.9: 11.24