HitPredict

Interactor 1: H2A (P84051)
Histone H2A
Gene: His2A

Interactor 2: RING1 (Q9VB08)
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RING1) (Sex comb extra protein) (dRING protein) (dRING1)
Gene: Sce

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	18923078
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Histone~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 124 Dm			1 435
+	Hs
		555425 H2AX_HUMAN (1-120): 6.84e-62: 187: 90.91		RING1_HUMAN (9-434): 1.73e-78: 250: 34.98
+	Hs
		391666 H2A1B_HUMAN (1-122): 3.57e-61: 185: 88.62		RING1_HUMAN (9-434): 1.73e-78: 250: 34.98
+	Hs
		555327 H2AX_HUMAN (1-120): 6.84e-62: 187: 90.91		BRCA1_HUMAN (31-391): 1.09e-52: 192: 13.68
+	Hs
		391581 H2A1B_HUMAN (1-122): 3.57e-61: 185: 88.62		BRCA1_HUMAN (31-391): 1.09e-52: 192: 13.68
+	Hs
		749544 H2A2C_HUMAN (1-122): 1.62e-61: 185: 89.43		BRCA1_HUMAN (31-391): 1.09e-52: 192: 13.68
+	Hs
		1216249 H2A2B_HUMAN (1-122): 1.38e-62: 188: 90.24		RING2_HUMAN (198-434): 9.74e-49: 171: 28.00
+	Hs
		555611 H2AX_HUMAN (1-120): 6.84e-62: 187: 90.91		RING2_HUMAN (198-434): 9.74e-49: 171: 28.00
+	Hs
		1087089 H2A2C_HUMAN (1-122): 1.62e-61: 185: 89.43		RING2_HUMAN (198-434): 9.74e-49: 171: 28.00
+	Hs
		1185208 H2A3_HUMAN (1-122): 2.09e-61: 185: 89.43		RING2_HUMAN (198-434): 9.74e-49: 171: 28.00
+	Hs
		391856 H2A1B_HUMAN (1-122): 3.57e-61: 185: 88.62		RING2_HUMAN (198-434): 9.74e-49: 171: 28.00
+	Hs
		555322 H2AX_HUMAN (1-120): 6.84e-62: 187: 90.91		BMI1_HUMAN (29-324): 2e-47: 167: 12.73
+	Hs
		391572 H2A1B_HUMAN (1-122): 3.57e-61: 185: 88.62		BMI1_HUMAN (29-324): 2e-47: 167: 12.73
+	Hs
		717876 H2A2C_HUMAN (1-122): 1.62e-61: 185: 89.43		BMI1_HUMAN (29-324): 2e-47: 167: 12.73
+	Hs
		555617 H2AX_HUMAN (1-120): 6.84e-62: 187: 90.91		BARD1_HUMAN (5-386): 3.77e-33: 134: 10.43
+	Hs
		1087090 H2A2C_HUMAN (1-122): 1.62e-61: 185: 89.43		BARD1_HUMAN (5-386): 3.77e-33: 134: 10.43
+	Hs
		391861 H2A1B_HUMAN (1-122): 3.57e-61: 185: 88.62		BARD1_HUMAN (5-386): 3.77e-33: 134: 10.43
+	Hs
		555627 H2AX_HUMAN (1-120): 6.84e-62: 187: 90.91		PCGF1_HUMAN (23-127): 1.04e-30: 120: 24.07
+	Hs
		391879 H2A1B_HUMAN (1-122): 3.57e-61: 185: 88.62		PCGF1_HUMAN (23-127): 1.04e-30: 120: 24.07
+	Hs
		555610 H2AX_HUMAN (1-120): 6.84e-62: 187: 90.91		UHRF1_HUMAN (5-111): 1.23e-26: 114: 20.56
+	Mm
		83335 H2A1B_MOUSE (1-122): 3.57e-61: 185: 88.62		UHRF1_MOUSE (5-111): 1.75e-21: 99.4: 22.43