HitPredict

Interactor 1: RHOG (P84095)
Rho-related GTP-binding protein RhoG
Gene: RHOG

Interactor 2: TIAM1 (Q13009)
Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1)
Gene: TIAM1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~Ras, PH~Ras, RBD~Ras, Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0008284 - positive regulation of cell population proliferation GO:0016601 - Rac protein signal transduction GO:0090630 - activation of GTPase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 1591
+	Mm
		925795 RAC1_MOUSE (1-191): 3.6e-82: 243: 71.88		TIAM1_MOUSE (1-1591): 0: 1886: 95.41
+	Hs
		925241 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		TIAM1_HUMAN (1-1591): 0: 1876: 100.00
+	Rn
		88818 RAC1_RAT (1-191): 3.6e-82: 243: 71.88		D3ZWV8_RAT (1-1591): 0: 1826: 93.18
+	Hs
		166482 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		MCF2L_HUMAN (658-1559): 1.12e-110: 381: 16.39
+	Hs
		925497 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		ARHG2_HUMAN (821-1575): 9.12e-97: 338: 13.13
+	Hs
		855782 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		VAV2_HUMAN (949-1591): 2.29e-96: 334: 14.91
+	Hs
		925271 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		ARHG7_HUMAN (818-1568): 7.77e-97: 333: 14.38
+	Hs
		925455 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		PREX1_HUMAN (991-1488): 1.48e-91: 331: 21.02
+	Hs
		925382 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		PREX2_HUMAN (1026-1488): 3.95e-90: 326: 19.03
+	Hs
		279854 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		TRIO_HUMAN (700-1587): 3.07e-89: 325: 17.13
+	Ce
		975575 RAC1_CAEEL (1-191): 4.3e-83: 245: 66.49		VAV_CAEEL (963-1590): 6.88e-89: 315: 16.99
+	Hs
		925527 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		SPT13_HUMAN (801-1473): 7.06e-90: 309: 17.13
+	Hs
		500934 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		MCF2_HUMAN (657-1476): 3.11e-87: 308: 15.21
+	Hs
		925289 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		ARHG6_HUMAN (815-1591): 1.89e-88: 308: 16.08
+	Hs
		548678 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		VAV_HUMAN (954-1525): 4.75e-87: 306: 15.72
+	Hs
		224711 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		KALRN_HUMAN (638-1589): 3.02e-81: 299: 13.06
+	Hs
		50580 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		PKHG3_HUMAN (984-1587): 7.98e-80: 291: 17.03
+	Hs
		925405 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		ARHGP_HUMAN (967-1498): 1.79e-80: 279: 17.24
+	Gg
		1141019 Q6LC82_CHICK (1-191): 3.6e-82: 243: 71.88		ARHG6_CHICK (991-1395): 5.42e-66: 241: 20.44
+	Hs
		925622 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		PKHG2_HUMAN (1040-1239): 7.09e-15: 82.8: 29.95