HitPredict

Interactor 1: RHOG (P84095)
Rho-related GTP-binding protein RhoG
Gene: RHOG

Interactor 2: DOCK1 (Q14185)
Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180)
Gene: DOCK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	12879077, 31871319
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	DHR-2_Lobe_B~Ras, DHR-2_Lobe_C~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 1865
+	Mm
		925807 RAC1_MOUSE (1-191): 3.6e-82: 243: 71.88		DOCK1_MOUSE (1-1865): 0: 2189: 96.46
+	Hs
		925276 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		DOCK1_HUMAN (1-1865): 0: 2184: 100.00
+	Hs
		925486 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		DOCK2_HUMAN (1-1805): 0: 1960: 59.80
+	Hs
		925620 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		DOCK5_HUMAN (1-1844): 0: 1934: 62.63
+	Hs
		951344 RHOG_HUMAN (1-191): 9.12e-82: 242: 100.00		DOCK5_HUMAN (1-1844): 0: 1934: 62.63
+	Hs
		925425 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		DOCK3_HUMAN (4-1851): 0: 1771: 36.75
+	Hs
		925429 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		DOCK4_HUMAN (4-1855): 0: 1748: 36.35
+	Dm
		776892 RAC1_DROME (1-191): 5.32e-79: 235: 67.71		Q8MQW7_DROME (665-1822): 0: 1067: 38.49
+	Hs
		925588 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		DOCK9_HUMAN (231-1004): 0: 654: 14.61
+	Hs
		951301 RHOG_HUMAN (1-191): 9.12e-82: 242: 100.00		DOCK9_HUMAN (231-1004): 0: 654: 14.61
+	Mm
		101404 CDC42_MOUSE (1-191): 1.3e-78: 234: 60.73		F8VPN7_MOUSE (231-987): 0: 659: 15.39
+	Mm
		57052 CDC42_MOUSE (1-191): 1.3e-78: 234: 60.73		DOC11_MOUSE (231-984): 0: 613: 14.50
+	Hs
		925332 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		DOC11_HUMAN (231-999): 0: 602: 13.91
+	Mm
		892732 CDC42_MOUSE (1-191): 1.3e-78: 234: 60.73		DOC10_MOUSE (1014-1657): 1.4e-173: 583: 16.14
+	Hs
		925518 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		DOCK6_HUMAN (303-978): 1.07e-138: 480: 11.88
+	Hs
		925526 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		DOCK7_HUMAN (736-996): 3.88e-50: 199: 10.47
+	Hs
		925448 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		DOCK8_HUMAN (707-1086): 1.69e-39: 164: 9.09
+	Hs
		496789 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		TAU_HUMAN (1502-1858): 1.32e-26: 120: 12.30
+	Hs
		297823 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		K0754_HUMAN (1537-1822): 8.69e-11: 69.8: 10.07
+	Hs
		297827 RHOG_HUMAN (1-191): 9.12e-82: 242: 100.00		K0754_HUMAN (1537-1822): 8.69e-11: 69.8: 10.07