HitPredict

Interactor 1: RHOG (P84095)
Rho-related GTP-binding protein RhoG
Gene: RHOG

Interactor 2: RGPA2 (Q2PPJ7)
Ral GTPase-activating protein subunit alpha-2 (250 kDa substrate of Akt) (AS250) (p220)
Gene: RALGAPA2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Rap_GAP~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0090630 - activation of GTPase activity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 191 Hs			1 1873
+	Hs
		564550 RHOQ_HUMAN (4-189): 5.74e-73: 220: 56.84		RGPA2_HUMAN (1-1873): 0: 2869: 100.00
+	Hs
		925359 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		RGPA1_HUMAN (1-851): 0: 1225: 48.66
+	Hs
		951081 RHOG_HUMAN (1-191): 9.12e-82: 242: 100.00		RGPA1_HUMAN (1-851): 0: 1225: 48.66
+	Hs
		894131 CDC42_HUMAN (1-191): 1.3e-78: 234: 60.73		RGPA1_HUMAN (1-851): 0: 1225: 48.66
+	Hs
		900583 RHOA_HUMAN (5-191): 1.26e-78: 234: 55.62		RGPA1_HUMAN (1-851): 0: 1225: 48.66
+	Hs
		892432 RAC3_HUMAN (1-177): 1.67e-75: 226: 72.88		RGPA1_HUMAN (1-851): 0: 1225: 48.66
+	Hs
		564573 RHOQ_HUMAN (4-189): 5.74e-73: 220: 56.84		RGPA1_HUMAN (1-851): 0: 1225: 48.66
+	Hs
		925407 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		RLGPB_HUMAN (993-1802): 3.58e-139: 473: 17.54
+	Hs
		951126 RHOG_HUMAN (1-191): 9.12e-82: 242: 100.00		RLGPB_HUMAN (993-1802): 3.58e-139: 473: 17.54
+	Hs
		894180 CDC42_HUMAN (1-191): 1.3e-78: 234: 60.73		RLGPB_HUMAN (993-1802): 3.58e-139: 473: 17.54
+	Hs
		900651 RHOA_HUMAN (5-191): 1.26e-78: 234: 55.62		RLGPB_HUMAN (993-1802): 3.58e-139: 473: 17.54
+	Hs
		892464 RAC3_HUMAN (1-177): 1.67e-75: 226: 72.88		RLGPB_HUMAN (993-1802): 3.58e-139: 473: 17.54
+	Hs
		564595 RHOQ_HUMAN (4-189): 5.74e-73: 220: 56.84		RLGPB_HUMAN (993-1802): 3.58e-139: 473: 17.54
+	Hs
		925514 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		SIPA1_HUMAN (1545-1859): 7.89e-90: 319: 21.23
+	Hs
		900790 RHOA_HUMAN (5-191): 1.26e-78: 234: 55.62		SIPA1_HUMAN (1545-1859): 7.89e-90: 319: 21.23
+	Hs
		230233 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		SI1L3_HUMAN (1534-1859): 2.76e-83: 306: 20.35
+	Dm
		776929 RAC1_DROME (1-191): 5.32e-79: 235: 67.71		X2JDH0_DROME (1505-1859): 1.71e-80: 297: 18.06
+	Dm
		776932 RAC1_DROME (1-191): 5.32e-79: 235: 67.71		X2JJU0_DROME (1505-1859): 1.6e-80: 297: 18.06