HitPredict

Interactor 1: RHOG (P84095)
Rho-related GTP-binding protein RhoG
Gene: RHOG

Interactor 2: PREX2 (Q70Z35)
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein (P-Rex2) (PtdIns(3,4,5)-dependent Rac exchanger 2) (DEP domain-containing protein 2)
Gene: PREX2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PDZ~Ras, PH~Ras, Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 1606
+	Hs
		925382 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		PREX2_HUMAN (1-1606): 0: 2094: 100.00
+	Hs
		925455 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		PREX1_HUMAN (4-1600): 0: 1874: 56.86
+	Hs
		925374 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		DNMBP_HUMAN (7-617): 2.5e-86: 314: 17.16
+	Hs
		951095 RHOG_HUMAN (1-191): 9.12e-82: 242: 100.00		DNMBP_HUMAN (7-617): 2.5e-86: 314: 17.16
+	Hs
		925527 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		SPT13_HUMAN (2-435): 5.45e-91: 312: 30.12
+	Hs
		925649 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		ARHG4_HUMAN (6-409): 1.69e-87: 303: 30.79
+	Hs
		548678 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		VAV_HUMAN (3-439): 1.18e-81: 290: 22.44
+	Hs
		925241 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		TIAM1_HUMAN (2-530): 2.31e-78: 289: 18.69
+	Hs
		50580 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		PKHG3_HUMAN (1-442): 8.9e-79: 288: 23.53
+	Hs
		950956 RHOG_HUMAN (1-191): 9.12e-82: 242: 100.00		TIAM1_HUMAN (2-530): 2.31e-78: 289: 18.69
+	Hs
		500934 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		MCF2_HUMAN (4-480): 4.6e-80: 287: 19.47
+	Hs
		50582 RHOG_HUMAN (1-191): 9.12e-82: 242: 100.00		PKHG3_HUMAN (1-442): 8.9e-79: 288: 23.53
+	Hs
		925727 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		PKHG1_HUMAN (4-537): 5.67e-78: 287: 19.15
+	Hs
		855782 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		VAV2_HUMAN (19-412): 4.52e-78: 280: 25.25
+	Rn
		88818 RAC1_RAT (1-191): 3.6e-82: 243: 71.88		D3ZWV8_RAT (9-398): 1.05e-72: 271: 22.38
+	Mm
		925795 RAC1_MOUSE (1-191): 3.6e-82: 243: 71.88		TIAM1_MOUSE (9-398): 1.46e-72: 270: 22.38
+	Hs
		166482 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		MCF2L_HUMAN (1-408): 1.95e-72: 267: 21.80
+	Hs
		925271 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		ARHG7_HUMAN (27-359): 3.82e-74: 266: 24.11
+	Hs
		925718 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		VAV3_HUMAN (12-354): 1.08e-71: 260: 24.13
+	Ce
		975575 RAC1_CAEEL (1-191): 4.3e-83: 245: 66.49		VAV_CAEEL (28-351): 1.99e-20: 100: 26.50