HitPredict

Interactor 1: RHOG (P84095)
Rho-related GTP-binding protein RhoG
Gene: RHOG

Interactor 2: ELMO1 (Q92556)
Engulfment and cell motility protein 1 (Protein ced-12 homolog)
Gene: ELMO1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.843

Property	Details
Experiments	21930703, 12879077, 33513601
Identification Methods	two hybrid, pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	PH_12~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007015 - actin filament organization GO:0016601 - Rac protein signal transduction GO:0030036 - actin cytoskeleton organization
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 191 Hs			1 727
+	Hs
		925482 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		ELMO1_HUMAN (1-727): 0: 1066: 100.00
+	Hs
		925522 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		ELMO2_HUMAN (1-724): 0: 983: 75.59
+	Hs
		951239 RHOG_HUMAN (1-191): 9.12e-82: 242: 100.00		ELMO2_HUMAN (1-724): 0: 983: 75.59
+	Hs
		545562 RAC2_HUMAN (1-191): 1.28e-78: 234: 71.35		ELMO2_HUMAN (1-724): 0: 983: 75.59
+	Hs
		545552 RAC2_HUMAN (1-191): 1.28e-78: 234: 71.35		ELMO3_HUMAN (1-727): 0: 932: 51.51
+	Ce
		104470 G5EBV3_CAEEL (2-191): 3.88e-79: 235: 60.00		CED12_CAEEL (27-720): 0: 664: 22.91
+	Hs
		951143 RHOG_HUMAN (1-191): 9.12e-82: 242: 100.00		ELMD2_HUMAN (248-492): 1.2e-50: 180: 17.07
+	Hs
		900680 RHOA_HUMAN (5-191): 1.26e-78: 234: 55.62		ELMD1_HUMAN (299-493): 3.22e-49: 178: 15.84