HitPredict

Interactor 1: SRSF3 (P84103)
Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3)
Gene: SRSF3

Interactor 2: SRSF1 (Q07955)
Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit)
Gene: SRSF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016607 - nuclear speck
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 164 Hs			1 248
+	Hs
		1028559 SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35		SRSF9_HUMAN (1-239): 2.72e-66: 206: 60.25
+	Hs
		1028673 SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35		SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48
+	Hs
		992750 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		SRSF9_HUMAN (1-239): 2.72e-66: 206: 60.25
+	Hs
		1028936 SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35		SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51
+	Hs
		992751 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48
+	Hs
		992752 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51
+	Hs
		993726 SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35		SRSF4_HUMAN (17-243): 1.36e-49: 171: 37.66
+	Hs
		992790 SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35		SRSF1_HUMAN (1-235): 1.04e-49: 165: 100.00
+	Hs
		992737 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		SRSF4_HUMAN (17-243): 1.36e-49: 171: 37.66
+	Hs
		992736 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		SRSF1_HUMAN (1-235): 1.04e-49: 165: 100.00
+	Mm
		936481 SRSF1_MOUSE (9-80): 1.1e-25: 100: 48.65		TIAR_MOUSE (10-207): 7.64e-40: 143: 18.83
+	Hs
		516466 SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00		PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67
+	Hs
		516478 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67
+	Hs
		951980 SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35		SRSF3_HUMAN (15-99): 9.33e-28: 105: 43.53
+	Dm
		970866 RBP1_DROME (1-80): 1.11e-28: 104: 66.67		RBP1_DROME (16-88): 9.45e-29: 107: 49.32
+	Mm
		952199 SRSF3_MOUSE (1-164): 6.39e-27: 100: 100.00		SRSF3_MOUSE (15-99): 9.33e-28: 105: 43.53
+	Zm
		41889 A0A1D6NTG8_MAIZE (10-113): 4.01e-27: 102: 38.89		A0A1D6NTG8_MAIZE (17-93): 1.02e-22: 94.1: 40.26
+	Hs
		474017 SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00		PAB4L_HUMAN (17-92): 5.07e-19: 86.6: 19.48
+	Mm
		857340 SRSF1_MOUSE (9-80): 1.1e-25: 100: 48.65		TIA1_MOUSE (115-203): 5.51e-10: 60.8: 11.70