HitPredict

Interactor 1: SRSF3 (P84103)
Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3)
Gene: SRSF3

Interactor 2: SRPK3 (Q9UPE1)
SRSF protein kinase 3 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1) (Serine/arginine-rich protein-specific kinase 3) (SR-protein-specific kinase 3) (Serine/threonine-protein kinase 23)
Gene: SRPK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	23602568
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 164 Hs			1 567
+	Hs
		992994 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		SRPK3_HUMAN (27-567): 5.16e-140: 418: 100.00
+	Hs
		625466 SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35		CDK2_HUMAN (274-566): 4.84e-82: 260: 17.97
+	Hs
		942687 SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35		SRPK2_HUMAN (297-566): 8.12e-72: 244: 57.69
+	Hs
		942594 SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00		SRPK2_HUMAN (297-566): 8.12e-72: 244: 57.69
+	Hs
		942611 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		SRPK2_HUMAN (297-566): 8.12e-72: 244: 57.69
+	Hs
		833887 SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35		CLK2_HUMAN (60-227): 1.39e-63: 218: 32.54
+	Hs
		1084378 SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35		SRPK1_HUMAN (368-566): 2.74e-59: 210: 67.84
+	Hs
		833865 SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00		CLK2_HUMAN (60-227): 1.39e-63: 218: 32.54
+	Hs
		833870 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		CLK2_HUMAN (60-227): 1.39e-63: 218: 32.54
+	Hs
		992944 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		CLK4_HUMAN (45-228): 8.59e-63: 215: 30.81
+	Hs
		992896 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		SRPK1_HUMAN (368-566): 2.74e-59: 210: 67.84
+	Hs
		1082558 SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35		MK14_HUMAN (66-259): 1.61e-45: 165: 21.78
+	Zm
		33400 A0A1D6M1U3_MAIZE (5-85): 1.01e-30: 115: 42.17		A0A1D6L2E7_MAIZE (69-220): 1.96e-11: 69.3: 33.33
+	Hs
		834053 SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35		CLK3_HUMAN (396-565): 4.23e-12: 70.9: 25.97
+	Hs
		833742 SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35		CLK1_HUMAN (405-566): 8.71e-11: 66.2: 26.01
+	Dm
		834161 RBP1_DROME (1-80): 1.11e-28: 104: 66.67		DOA_DROME (396-566): 7.94e-12: 70.1: 25.41
+	Hs
		834022 SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00		CLK3_HUMAN (396-565): 4.23e-12: 70.9: 25.97
+	Hs
		834026 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		CLK3_HUMAN (396-565): 4.23e-12: 70.9: 25.97
+	Hs
		833711 SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00		CLK1_HUMAN (405-566): 8.71e-11: 66.2: 26.01
+	Hs
		833720 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		CLK1_HUMAN (405-566): 8.71e-11: 66.2: 26.01