HitPredict

Interactor 1: H33 (P84243)
Histone H3.3
Gene: H3-3A

Interactor 2: EHMT2 (Q96KQ7)
Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a)
Gene: EHMT2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.898

Property	Details
Experiments	16189514, 33961781, 36089195, 17403666
Identification Methods	two hybrid, affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, two hybrid pooling approach
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Histone~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0007286 - spermatid development
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 136 Hs			1 1210
+	Hs
		935126 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		EHMT2_HUMAN (21-1210): 0: 909: 100.00
+	Hs
		1086279 H31T_HUMAN (1-136): 2.58e-59: 181: 93.38		EHMT2_HUMAN (21-1210): 0: 909: 100.00
+	Hs
		1174632 H32_HUMAN (1-136): 5.32e-59: 180: 97.06		EHMT2_HUMAN (21-1210): 0: 909: 100.00
+	Mm
		952777 H33_MOUSE (1-136): 1.12e-59: 182: 100.00		EHMT2_MOUSE (9-1210): 0: 870: 94.44
+	Hs
		935251 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		EHMT1_HUMAN (1-1209): 0: 685: 45.63
+	Hs
		952633 H33_HUMAN (1-136): 1.12e-59: 182: 100.00		EHMT1_HUMAN (1-1209): 0: 685: 45.63
+	Hs
		1086320 H31T_HUMAN (1-136): 2.58e-59: 181: 93.38		EHMT1_HUMAN (1-1209): 0: 685: 45.63
+	Dm
		115784 H3_DROME (1-136): 5.32e-59: 180: 97.06		M9PGH7_DROME (1-1210): 5.56e-155: 507: 23.23
+	Hs
		934668 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		ANK2_HUMAN (441-952): 4.59e-91: 326: 18.61
+	Hs
		965127 H32_HUMAN (1-136): 5.32e-59: 180: 97.06		ANK2_HUMAN (441-952): 4.59e-91: 326: 18.61
+	At
		886462 H33_ARATH (1-136): 3.83e-60: 183: 95.59		SUVH4_ARATH (911-1177): 1.21e-82: 285: 29.13
+	Hs
		935237 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		SUV92_HUMAN (928-1177): 2.53e-85: 285: 35.93
+	Hs
		952627 H33_HUMAN (1-136): 1.12e-59: 182: 100.00		SUV92_HUMAN (928-1177): 2.53e-85: 285: 35.93
+	Hs
		203659 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		SUV91_HUMAN (861-1179): 1.67e-78: 266: 30.51
+	Hs
		203664 H33_HUMAN (1-136): 1.12e-59: 182: 100.00		SUV91_HUMAN (861-1179): 1.67e-78: 266: 30.51
+	Hs
		203722 H32_HUMAN (1-136): 5.32e-59: 180: 97.06		SUV91_HUMAN (861-1179): 1.67e-78: 266: 30.51
+	Hs
		934710 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		ANK3_HUMAN (624-1084): 7.02e-66: 248: 17.79
+	Sp
		223811 H31_SCHPO (1-136): 1.12e-57: 177: 91.91		CLR4_SCHPO (924-1176): 3.8e-36: 145: 34.95
+	Dm
		356073 H3_DROME (1-136): 5.32e-59: 180: 97.06		SUV39_DROME (934-1176): 1.28e-28: 125: 36.84
+	At
		886666 H31_ARATH (1-136): 1.05e-58: 179: 94.85		SUVR2_ARATH (925-1176): 6.59e-29: 126: 30.97