HitPredict

Interactor 1: H33 (P84243)
Histone H3.3
Gene: H3-3A

Interactor 2: SETB2 (Q96T68)
Histone-lysine N-methyltransferase SETDB2 (EC 2.1.1.366) (Chronic lymphocytic leukemia deletion region gene 8 protein) (Lysine N-methyltransferase 1F) (SET domain bifurcated 2)
Gene: SETDB2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36089195
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 136 Hs			1 719
+	Mm
		952777 H33_MOUSE (1-136): 1.12e-59: 182: 100.00		EHMT2_MOUSE (509-715): 1.43e-59: 220: 24.78
+	Hs
		935126 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		EHMT2_HUMAN (509-715): 1.33e-58: 217: 24.78
+	Hs
		935251 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		EHMT1_HUMAN (504-715): 1.08e-58: 217: 21.14
+	Hs
		952553 H33_HUMAN (1-136): 1.12e-59: 182: 100.00		EHMT2_HUMAN (509-715): 1.33e-58: 217: 24.78
+	Hs
		952633 H33_HUMAN (1-136): 1.12e-59: 182: 100.00		EHMT1_HUMAN (504-715): 1.08e-58: 217: 21.14
+	Hs
		1086279 H31T_HUMAN (1-136): 2.58e-59: 181: 93.38		EHMT2_HUMAN (509-715): 1.33e-58: 217: 24.78
+	Hs
		935237 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		SUV92_HUMAN (255-557): 2.04e-50: 183: 16.56
+	Hs
		952627 H33_HUMAN (1-136): 1.12e-59: 182: 100.00		SUV92_HUMAN (255-557): 2.04e-50: 183: 16.56
+	Hs
		935205 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		NSD3_HUMAN (208-575): 6.65e-47: 181: 13.96
+	At
		886462 H33_ARATH (1-136): 3.83e-60: 183: 95.59		SUVH4_ARATH (507-719): 1.31e-47: 180: 18.73
+	Hs
		952607 H33_HUMAN (1-136): 1.12e-59: 182: 100.00		NSD3_HUMAN (208-575): 6.65e-47: 181: 13.96
+	Hs
		935129 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		NSD1_HUMAN (172-575): 6.63e-45: 176: 12.27
+	Hs
		952555 H33_HUMAN (1-136): 1.12e-59: 182: 100.00		NSD1_HUMAN (172-575): 6.63e-45: 176: 12.27
+	Hs
		1086280 H31T_HUMAN (1-136): 2.58e-59: 181: 93.38		NSD1_HUMAN (172-575): 6.63e-45: 176: 12.27
+	Hs
		203659 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		SUV91_HUMAN (254-444): 2.77e-44: 166: 22.66
+	Hs
		203664 H33_HUMAN (1-136): 1.12e-59: 182: 100.00		SUV91_HUMAN (254-444): 2.77e-44: 166: 22.66
+	Hs
		935276 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		ASH1L_HUMAN (267-544): 4.37e-41: 164: 12.19
+	Hs
		952649 H33_HUMAN (1-136): 1.12e-59: 182: 100.00		ASH1L_HUMAN (267-544): 4.37e-41: 164: 12.19
+	Hs
		935204 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		SETD2_HUMAN (305-493): 4.29e-38: 155: 17.33
+	Hs
		934780 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		SETB1_HUMAN (525-644): 3.26e-11: 69.1: 12.95