HitPredict

Interactor 1: H33 (P84244)
Histone H3.3
Gene: H3-3a

Interactor 2: SET1B (Q8CFT2)
Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (SET domain-containing protein 1B)
Gene: Setd1b

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	24368734
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Histone~N-SET, Histone~SET
Common GO terms	GO:0005634 - nucleus GO:0005694 - chromosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 136 Mm			1 1985
+	Hs
		935374 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		SET1B_HUMAN (18-1985): 2.52e-141: 489: 84.52
+	Hs
		935368 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		KMT2B_HUMAN (1084-1985): 3.45e-80: 297: 21.70
+	Mm
		139069 H33_MOUSE (1-136): 1.12e-59: 182: 100.00		KMT2B_MOUSE (1218-1985): 2.14e-73: 275: 22.59
+	Hs
		935276 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		ASH1L_HUMAN (250-1984): 8.84e-71: 267: 10.37
+	Hs
		934681 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		KMT2A_HUMAN (1385-1985): 1.28e-68: 260: 23.66
+	Hs
		935205 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		NSD3_HUMAN (1737-1984): 1.72e-63: 241: 24.60
+	Mm
		952754 H33_MOUSE (1-136): 1.12e-59: 182: 100.00		Q6AXH7_MOUSE (1619-1969): 6.72e-66: 241: 17.02
+	Mm
		952747 H33_MOUSE (1-136): 1.12e-59: 182: 100.00		EZH2_MOUSE (1508-1969): 2.47e-65: 240: 15.93
+	Hs
		934804 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		EZH2_HUMAN (1472-1969): 2.77e-64: 236: 15.23
+	Hs
		331780 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		NSD2_HUMAN (1736-1984): 1.63e-61: 235: 24.90
+	Hs
		935237 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		SUV92_HUMAN (1667-1985): 6.7e-67: 235: 16.95
+	Hs
		203659 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		SUV91_HUMAN (1669-1984): 3.4e-66: 233: 16.94
+	Mm
		93307 H33_MOUSE (1-136): 1.12e-59: 182: 100.00		SET1A_MOUSE (438-1985): 4.49e-61: 234: 23.15
+	Hs
		203664 H33_HUMAN (1-136): 1.12e-59: 182: 100.00		SUV91_HUMAN (1669-1984): 3.4e-66: 233: 16.94
+	Hs
		165661 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		SET1A_HUMAN (445-1985): 9.17e-60: 230: 21.87
+	Hs
		935004 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		KMT2C_HUMAN (1783-1985): 3.34e-57: 223: 38.39
+	Hs
		935204 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		SETD2_HUMAN (1754-1984): 2.22e-56: 220: 23.85
+	Hs
		935129 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		NSD1_HUMAN (1739-1984): 9.21e-56: 217: 23.60
+	Hs
		152625 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		KMT2D_HUMAN (1845-1985): 4.61e-17: 90.5: 46.85
+	Mm
		101827 H33_MOUSE (1-136): 1.12e-59: 182: 100.00		F8WI37_MOUSE (952-1642): 2.54e-10: 68.2: 13.51