HitPredict

Interactor 1: CSN5 (P91001)
COP9 signalosome complex subunit 5 (Signalosome subunit 5) (EC 3.4.-.-) (JAB1 homolog)
Gene: csn-5

Interactor 2: CSN1 (Q9GS00)
COP9 signalosome complex subunit 1 (Signalosome subunit 1)
Gene: csn-1

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.775

Property	Details
Experiments	12781129, 17403899
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	JAB~PCI
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0008180 - COP9 signalosome GO:0048477 - oogenesis GO:0060184 - cell cycle switching and 1 others more... GO:1905879 - regulation of oogenesis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 368 Ce			1 601
+	Mm
		102340 CSN5_MOUSE (10-328): 3.81e-118: 347: 55.93		G3UXW9_MOUSE (23-550): 4.52e-150: 444: 24.16
+	Hs
		1024199 CSN5_HUMAN (10-328): 3.72e-118: 347: 55.93		CSN1_HUMAN (44-550): 1.34e-139: 416: 24.61
+	Mm
		193526 CSN5_MOUSE (10-328): 3.81e-118: 347: 55.93		CSN1_MOUSE (58-550): 1.11e-139: 416: 24.35
+	At
		799472 CSN5A_ARATH (9-363): 3.58e-120: 353: 50.00		CSN1_ARATH (58-540): 4.73e-121: 367: 23.89
+	At
		799480 CSN5B_ARATH (9-363): 1.33e-117: 346: 50.00		CSN1_ARATH (58-540): 4.73e-121: 367: 23.89
+	Ce
		136314 CSN5_CAEEL (1-368): 2.04e-144: 415: 100.00		CSN2_CAEEL (110-501): 4.43e-87: 280: 11.08
+	Dm
		1277039 CSN5_DROME (10-328): 1.58e-128: 373: 57.72		CSN2_DROME (110-527): 3.12e-100: 313: 11.42
+	Mm
		193516 CSN5_MOUSE (10-328): 3.81e-118: 347: 55.93		CSN2_MOUSE (85-527): 8.76e-104: 322: 10.79
+	Hs
		897288 CSN5_HUMAN (10-328): 3.72e-118: 347: 55.93		CSN2_HUMAN (85-527): 8.76e-104: 322: 10.79
+	At
		1227249 CSN5A_ARATH (9-363): 3.58e-120: 353: 50.00		CSN2_ARATH (85-536): 1.25e-98: 309: 9.68
+	An
		1124330 CSN5_EMENI (12-331): 8.37e-106: 316: 50.76		CSN1_EMENI (24-552): 5.25e-110: 340: 22.10
+	At
		1258867 CSN5B_ARATH (9-363): 1.33e-117: 346: 50.00		CSN2_ARATH (85-536): 1.25e-98: 309: 9.68
+	Hs
		130893 PSDE_HUMAN (46-321): 7.05e-86: 264: 28.98		PSMD6_HUMAN (108-523): 1.77e-111: 340: 15.14
+	An
		1124314 CSN5_EMENI (12-331): 8.37e-106: 316: 50.76		CSN2_EMENI (87-518): 2.25e-85: 277: 11.30
+	Dm
		1358521 PSDE_DROME (39-321): 2.33e-88: 270: 29.11		PSMD6_DROME (107-523): 7.33e-103: 318: 13.43
+	Hs
		121632 PSDE_HUMAN (46-321): 7.05e-86: 264: 28.98		PSD11_HUMAN (111-529): 5.76e-103: 319: 14.69
+	Dm
		1180711 PSDE_DROME (39-321): 2.33e-88: 270: 29.11		PSD11_DROME (120-530): 1.48e-99: 311: 13.06
+	Sp
		293445 CSN5_SCHPO (26-324): 5.07e-91: 276: 39.02		CSN2_SCHPO (110-521): 2.8e-85: 274: 11.32
+	Hs
		121889 PSDE_HUMAN (46-321): 7.05e-86: 264: 28.98		PSD12_HUMAN (62-521): 7.94e-78: 255: 12.25
+	Zm
		46755 B4FLQ8_MAIZE (34-321): 3.04e-91: 277: 30.00		A0A3L6E9W8_MAIZE (321-555): 2.19e-52: 188: 15.48