HitPredict

Interactor 1: MCM2 (P97310)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)
Gene: MCM2

Interactor 2: AIRE (Q9Z0E3)
Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog) (APECED protein homolog)
Gene: AIRE

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	20085707
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0042393 - histone binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 904 Mm			1 552
+	Hs
		217459 MCM2_HUMAN (1-904): 0: 1033: 95.58		AIRE_HUMAN (17-549): 2.65e-119: 364: 70.28
+	Hs
		832409 MCM2_HUMAN (1-904): 0: 1033: 95.58		CHD3_HUMAN (32-431): 3.08e-43: 168: 15.17
+	Mm
		831956 MCM5_MOUSE (194-900): 0: 702: 30.39		AIRE_MOUSE (1-552): 2.26e-142: 424: 100.00
+	Hs
		832782 MCM2_HUMAN (1-904): 0: 1033: 95.58		TRI33_HUMAN (345-516): 8.78e-15: 79.8: 18.50
+	Hs
		170301 MCM2_HUMAN (1-904): 0: 1033: 95.58		TIF1A_HUMAN (407-484): 3.03e-14: 77.9: 26.92
+	Mm
		956211 MCM6_MOUSE (186-827): 0: 656: 30.44		AIRE_MOUSE (1-552): 2.26e-142: 424: 100.00
+	Hs
		217452 MCM5_HUMAN (168-900): 0: 708: 29.24		AIRE_HUMAN (17-549): 2.65e-119: 364: 70.28
+	Hs
		217480 MCM6_HUMAN (179-824): 0: 653: 30.69		AIRE_HUMAN (17-549): 2.65e-119: 364: 70.28
+	Hs
		708618 MCM5_HUMAN (168-900): 0: 708: 29.24		CHD3_HUMAN (32-431): 3.08e-43: 168: 15.17
+	Hs
		708544 MCM4_HUMAN (21-869): 0: 793: 28.09		TRI33_HUMAN (345-516): 8.78e-15: 79.8: 18.50
+	Hs
		170275 MCM4_HUMAN (21-869): 0: 793: 28.09		TIF1A_HUMAN (407-484): 3.03e-14: 77.9: 26.92
+	Hs
		627247 MCM3_HUMAN (193-897): 0: 656: 28.67		CHD3_HUMAN (32-431): 3.08e-43: 168: 15.17
+	Hs
		708880 MCM7_HUMAN (188-886): 0: 656: 27.41		CHD3_HUMAN (32-431): 3.08e-43: 168: 15.17
+	Dm
		1099476 MCM4_DROME (44-869): 0: 742: 26.64		KDM5_DROME (428-485): 9.65e-12: 70.2: 18.97
+	Hs
		627266 MCM3_HUMAN (193-897): 0: 656: 28.67		CHD4_HUMAN (66-540): 6.09e-24: 109: 12.50
+	Hs
		1055555 MCM6_HUMAN (179-824): 0: 653: 30.69		CHD4_HUMAN (66-540): 6.09e-24: 109: 12.50
+	Hs
		709113 MCM7_HUMAN (188-886): 0: 656: 27.41		TRI33_HUMAN (345-516): 8.78e-15: 79.8: 18.50
+	Hs
		170276 MCM7_HUMAN (188-886): 0: 656: 27.41		TIF1A_HUMAN (407-484): 3.03e-14: 77.9: 26.92
+	Hs
		170364 MCM6_HUMAN (179-824): 0: 653: 30.69		TIF1A_HUMAN (407-484): 3.03e-14: 77.9: 26.92
+	Hs
		709005 MCM7_HUMAN (188-886): 0: 656: 27.41		PF21A_HUMAN (400-485): 6.75e-12: 70.1: 18.61