HitPredict

Interactor 1: MEIS2 (P97367)
Homeobox protein Meis2 (Meis1-related protein 1)
Gene: MEIS2

Interactor 2: EMX1 (Q04742)
Homeobox protein EMX1 (Empty spiracles homolog 1) (Empty spiracles-like protein 1)
Gene: EMX1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	20211142
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Homeobox_KN~Homeodomain
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0007420 - brain development
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 477 Mm			1 257
+	Hs
		154467 MEIS2_HUMAN (1-477): 1.57e-155: 452: 99.58		TLX1_HUMAN (90-231): 1.84e-35: 130: 31.13
+	Hs
		67814 MEIS2_HUMAN (1-477): 1.57e-155: 452: 99.58		NOTO_HUMAN (157-218): 2.22e-13: 69.7: 54.84
+	Hs
		129972 MEIS1_HUMAN (1-382): 4.16e-116: 348: 82.72		EMX2_HUMAN (1-257): 8.58e-40: 140: 60.30
+	Hs
		129968 MEIS1_HUMAN (1-382): 4.16e-116: 348: 82.72		TLX1_HUMAN (90-231): 1.84e-35: 130: 31.13
+	Mm
		1141920 MEIS1_MOUSE (1-382): 1.13e-115: 347: 82.72		Q9QX99_MOUSE (90-231): 3.2e-35: 130: 31.13
+	Mm
		453088 MEIS1_MOUSE (1-382): 1.13e-115: 347: 82.72		HXB8_MOUSE (2-248): 5.19e-34: 124: 22.40
+	Mm
		678762 MEIS1_MOUSE (1-382): 1.13e-115: 347: 82.72		HXA2_MOUSE (60-232): 5.05e-31: 119: 26.74
+	Mm
		857948 MEIS1_MOUSE (1-382): 1.13e-115: 347: 82.72		PDX1_MOUSE (22-247): 9.13e-32: 119: 18.58
+	Mm
		446924 MEIS1_MOUSE (1-382): 1.13e-115: 347: 82.72		HXA5_MOUSE (11-231): 6.47e-30: 114: 20.81
+	Hs
		129960 MEIS1_HUMAN (1-382): 4.16e-116: 348: 82.72		TLX2_HUMAN (126-232): 4.09e-13: 69.3: 42.48
+	Hs
		129959 MEIS1_HUMAN (1-382): 4.16e-116: 348: 82.72		TLX3_HUMAN (158-231): 1.2e-12: 68.2: 47.30
+	Dm
		221152 HTH_DROME (1-396): 2.67e-85: 272: 45.27		ABDA_DROME (100-231): 1.8e-34: 132: 27.27
+	Dm
		221160 HTH_DROME (1-396): 2.67e-85: 272: 45.27		UBX_DROME (39-220): 1.28e-29: 116: 20.48
+	Mm
		453090 PKNX2_MOUSE (14-398): 2.47e-66: 222: 34.44		HXB8_MOUSE (2-248): 5.19e-34: 124: 22.40
+	Hs
		829802 PKNX1_HUMAN (53-460): 5.81e-67: 223: 32.24		HXA1_HUMAN (3-232): 6.59e-32: 121: 23.48
+	Hs
		174014 PKNX1_HUMAN (53-460): 5.81e-67: 223: 32.24		SHOX_HUMAN (148-221): 7.85e-32: 120: 40.54
+	Mm
		447608 PKNX2_MOUSE (14-398): 2.47e-66: 222: 34.44		HXA6_MOUSE (8-231): 1.76e-31: 117: 12.78
+	Hs
		453053 PBX1_HUMAN (196-458): 4.54e-51: 181: 20.44		HXB7_HUMAN (34-229): 7e-34: 123: 19.39
+	Hs
		174011 PBX1_HUMAN (196-458): 4.54e-51: 181: 20.44		SHOX_HUMAN (148-221): 7.85e-32: 120: 40.54
+	Hs
		446865 PBX1_HUMAN (196-458): 4.54e-51: 181: 20.44		HXD4_HUMAN (42-256): 8.14e-31: 116: 19.07