HitPredict

Interactor 1: GRM1 (P97772)
Metabotropic glutamate receptor 1 (mGluR1)
Gene: GRM1

Interactor 2: HOME2 (Q9QWW1)
Homer protein homolog 2 (Homer-2) (Cupidin) (VASP/Ena-related gene up-regulated during seizure and LTP 2) (Vesl-2)
Gene: Homer2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	10493740
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007216 - G protein-coupled glutamate receptor signaling pathway GO:0014069 - postsynaptic density GO:0030425 - dendrite GO:0043025 - neuronal cell body and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1199 Mm			1 354
+	Rn
		292329 GRM1_RAT (1-1199): 0: 1262: 98.33		HOME2_RAT (1-354): 1.18e-55: 187: 98.59
+	Mm
		956898 GRM1_MOUSE (1-1199): 0: 1261: 100.00		HOME1_MOUSE (1-350): 5.59e-49: 170: 50.55
+	Rn
		616098 GRM1_RAT (1-1199): 0: 1262: 98.33		HOME1_RAT (1-350): 3.1e-48: 168: 50.55
+	Rn
		616099 GRM1_RAT (1-1199): 0: 1262: 98.33		HOME3_RAT (3-350): 3.71e-48: 167: 45.43
+	Hs
		1029211 GRM1_HUMAN (1-1199): 0: 1235: 93.43		HOME1_HUMAN (1-350): 2.35e-52: 178: 50.86
+	Mm
		1113352 GRM5_MOUSE (30-1199): 0: 1135: 58.95		HOME2_MOUSE (1-354): 7.07e-56: 187: 100.00
+	Mm
		1113353 GRM5_MOUSE (30-1199): 0: 1135: 58.95		HOME1_MOUSE (1-350): 5.59e-49: 170: 50.55
+	Rn
		680341 GRM5_RAT (30-1199): 0: 1131: 59.03		HOME1_RAT (1-350): 3.1e-48: 168: 50.55
+	Hs
		783783 GRM5_HUMAN (30-1199): 0: 1115: 58.64		HOME1_HUMAN (1-350): 2.35e-52: 178: 50.86
+	Rn
		936851 GRM8_RAT (6-896): 0: 884: 39.05		ROCK2_RAT (20-346): 1.02e-27: 116: 12.13
+	Dm
		115347 GRM_DROME (12-920): 0: 843: 36.42		M9PEX1_DROME (1-350): 1.59e-28: 116: 30.00
+	Hs
		148808 GRM2_HUMAN (31-893): 0: 833: 42.37		CTRO_HUMAN (19-352): 3.61e-16: 82: 14.25