HitPredict

Interactor 1: SHPS1 (P97797)
Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (mSIRP-alpha1) (p84) (CD antigen CD172a)
Gene: Sirpa

Interactor 2: CD47 (Q61735)
Leukocyte surface antigen CD47 (Integrin-associated protein) (IAP) (CD antigen CD47)
Gene: CD47

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.806

The method score is based on:

Property	Details
Experiments	18045614, 18633106
Identification Methods	pull down, anti tag coimmunoprecipitation, surface plasmon resonance
Interaction Type	direct interaction, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	V-set~V-set_CD47
Common GO terms	GO:0005886 - plasma membrane GO:0009986 - cell surface GO:0016477 - cell migration GO:0045428 - regulation of nitric oxide biosynthetic process GO:0050765 - negative regulation of phagocytosis and 4 others more... GO:0050766 - positive regulation of phagocytosis GO:0071346 - cellular response to type II interferon GO:0071347 - cellular response to interleukin-1 GO:0086080 - protein binding involved in heterotypic cell-cell adhesion
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1	513
Mm

1	303

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024