HitPredict

Interactor 1: DLGP2 (P97837)
Disks large-associated protein 2 (DAP-2) (PSD-95/SAP90-binding protein 2) (SAP90/PSD-95-associated protein 2) (SAPAP2)
Gene: Dlgap2

Interactor 2: SHAN1 (Q9WV48)
SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (GKAP/SAPAP-interacting protein) (SPANK-1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP) (Synamon)
Gene: Shank1

Species: Rattus norvegicus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	10488079
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	GKAP~PDZ_6
Common GO terms	GO:0030425 - dendrite GO:0043197 - dendritic spine GO:0045211 - postsynaptic membrane GO:0050804 - modulation of chemical synaptic transmission GO:0098978 - glutamatergic synapse
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1059 Rn			1 2167
+	Rn
		956998 DLGP1_RAT (80-1059): 0: 1113: 50.24		SHAN1_RAT (1-2167): 1.05e-159: 548: 100.00
+	Mm
		88376 DLGP1_MOUSE (80-1059): 0: 1109: 50.24		SHAN1_MOUSE (1-2167): 3.82e-160: 549: 99.31
+	Hs
		145958 DLGP1_HUMAN (80-1059): 0: 1134: 50.98		SHAN1_HUMAN (1-2167): 1.58e-145: 505: 90.79
+	Hs
		1349917 DLGP2_HUMAN (1-1059): 0: 1460: 88.95		SHAN2_HUMAN (1063-2167): 2.83e-30: 134: 12.57
+	Mm
		1116003 DLGP2_MOUSE (1-1059): 0: 1482: 97.55		SHAN3_MOUSE (297-1858): 2.2e-18: 94.7: 12.80
+	Hs
		1316300 DLGP2_HUMAN (1-1059): 0: 1460: 88.95		SHAN3_HUMAN (297-1859): 5.83e-15: 83.5: 12.56
+	Rn
		956997 DLGP1_RAT (80-1059): 0: 1113: 50.24		SHAN2_RAT (1129-2167): 1.93e-46: 186: 15.54
+	Mm
		1194593 DLGP1_MOUSE (80-1059): 0: 1109: 50.24		SHAN2_MOUSE (1129-2167): 4.78e-47: 188: 15.75
+	Hs
		145956 DLGP1_HUMAN (80-1059): 0: 1134: 50.98		SHAN2_HUMAN (1063-2167): 2.83e-30: 134: 12.57
+	Hs
		145954 DLGP1_HUMAN (80-1059): 0: 1134: 50.98		SHAN3_HUMAN (297-1859): 5.83e-15: 83.5: 12.56
+	Mm
		1116115 DLGP1_MOUSE (80-1059): 0: 1109: 50.24		SHAN3_MOUSE (297-1858): 2.2e-18: 94.7: 12.80
+	Rn
		956996 DLGP1_RAT (80-1059): 0: 1113: 50.24		SHAN3_RAT (297-1837): 4.99e-16: 87: 11.94
+	Hs
		327248 DLGP3_HUMAN (80-1059): 0: 1038: 44.85		SHAN2_HUMAN (1063-2167): 2.83e-30: 134: 12.57
+	Hs
		327247 DLGP3_HUMAN (80-1059): 0: 1038: 44.85		SHAN3_HUMAN (297-1859): 5.83e-15: 83.5: 12.56
+	Rn
		102520 G3V7T8_RAT (80-1059): 0: 1021: 44.42		SHAN3_RAT (297-1837): 4.99e-16: 87: 11.94
+	Mm
		1115961 DLGP3_MOUSE (80-1059): 0: 1012: 44.33		SHAN3_MOUSE (297-1858): 2.2e-18: 94.7: 12.80
+	Hs
		1357785 DLGP4_HUMAN (80-1059): 0: 930: 41.09		SHAN2_HUMAN (1063-2167): 2.83e-30: 134: 12.57
+	Hs
		1316315 DLGP4_HUMAN (80-1059): 0: 930: 41.09		SHAN3_HUMAN (297-1859): 5.83e-15: 83.5: 12.56
+	Mm
		69915 DLGP4_MOUSE (80-1059): 0: 903: 41.09		SHAN3_MOUSE (297-1858): 2.2e-18: 94.7: 12.80