HitPredict

Interactor 1: DAB2 (P98082)
Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2)
Gene: DAB2

Interactor 2: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.620

Property	Details
Experiments	14596919, 19531213
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0006915 - apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 770 Hs			1 665
+	Mm
		957150 DAB2_MOUSE (1-770): 1.47e-81: 278: 82.15		SH3K1_MOUSE (1-665): 4.53e-118: 370: 87.59
+	Hs
		269176 DAB1_HUMAN (16-597): 1.41e-40: 159: 24.62		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		1191815 ANS1B_HUMAN (12-227): 1.36e-43: 172: 19.01		CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22
+	Hs
		557659 DAB2_HUMAN (1-770): 3.91e-90: 301: 100.00		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		924477 DAB2_HUMAN (1-770): 3.91e-90: 301: 100.00		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Mm
		957139 DAB2_MOUSE (1-770): 1.47e-81: 278: 82.15		GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91
+	Hs
		957186 DAB2_HUMAN (1-770): 3.91e-90: 301: 100.00		ITSN1_HUMAN (68-454): 2.48e-21: 101: 14.01
+	Mm
		957157 DAB2_MOUSE (1-770): 1.47e-81: 278: 82.15		ITSN1_MOUSE (120-519): 1.9e-19: 95.5: 14.11
+	Mm
		957144 DAB2_MOUSE (1-770): 1.47e-81: 278: 82.15		NOSTN_MOUSE (240-335): 1.6e-09: 62.8: 39.58
+	Mm
		956235 DAB1_MOUSE (16-597): 6.31e-41: 160: 24.27		NCK1_MOUSE (104-421): 1.23e-32: 131: 15.93
+	Hs
		269120 DAB1_HUMAN (16-597): 1.41e-40: 159: 24.62		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Rn
		924995 SHC1_RAT (6-323): 7.39e-40: 155: 10.62		GRB2_RAT (2-158): 6.97e-33: 128: 19.91
+	Hs
		269148 DAB1_HUMAN (16-597): 1.41e-40: 159: 24.62		ITSN1_HUMAN (68-454): 2.48e-21: 101: 14.01
+	Mm
		1206702 ANS1B_MOUSE (12-230): 5.35e-41: 164: 18.67		ITSN1_MOUSE (120-519): 1.9e-19: 95.5: 14.11
+	Hs
		209098 ANS1B_HUMAN (12-227): 1.36e-43: 172: 19.01		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77
+	Hs
		208964 DAB1_HUMAN (16-597): 1.41e-40: 159: 24.62		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77
+	Mm
		1206687 ANS1B_MOUSE (12-230): 5.35e-41: 164: 18.67		ARHG7_MOUSE (228-354): 2.05e-13: 75.9: 21.88
+	Mm
		223010 DAB1_MOUSE (16-597): 6.31e-41: 160: 24.27		NCK2_MOUSE (184-428): 6.56e-15: 78.9: 12.41
+	Dm
		112569 NUMB_DROME (24-530): 3.9e-41: 160: 12.25		M9ND00_DROME (254-450): 4.79e-13: 74.7: 12.56
+	Hs
		235561 ANS1A_HUMAN (1-227): 5e-36: 148: 19.05		VINEX_HUMAN (67-445): 2.37e-15: 81.7: 19.82