HitPredict

Interactor 1: LRP2 (P98164)
Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)
Gene: LRP2

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35563538
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 4655 Hs			1 768
+	Hs
		1042190 SORL_HUMAN (166-470): 5.79e-19: 98: 16.82		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		351068 LDLR_HUMAN (927-1187): 1.96e-15: 86: 17.65		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		254259 LRP4_HUMAN (3839-4093): 6.21e-15: 84.9: 22.90		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1041542 LRP8_HUMAN (3464-3669): 8.96e-14: 80.7: 21.92		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		957518 VLDLR_HUMAN (923-1143): 3.08e-10: 69.1: 15.11		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		992663 LRP1_HUMAN (1102-1387): 4.45e-09: 65.6: 13.59		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042703 LRP1B_HUMAN (4-204): 6.71e-09: 64.9: 16.16		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		537517 NID1_HUMAN (308-418): 7.69e-09: 64.5: 17.89		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1043623 LRP1B_HUMAN (4-204): 6.71e-09: 64.9: 16.16		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		1041124 SORL_HUMAN (166-470): 5.79e-19: 98: 16.82		CUL1_HUMAN (18-768): 0: 707: 30.57