HitPredict

Interactor 1: XIAP (P98170)
E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
Gene: XIAP

Interactor 2: RN166 (Q96A37)
E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING finger protein 166) (RING-type E3 ubiquitin transferase RNF166)
Gene: RNF166

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	33130818
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0046872 - metal ion binding GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 497 Hs			1 237
+	Hs
		957805 XIAP_HUMAN (1-497): 0: 569: 100.00		TRAF6_HUMAN (8-235): 8.66e-29: 114: 17.83
+	Hs
		957692 XIAP_HUMAN (1-497): 0: 569: 100.00		TRAF2_HUMAN (15-186): 9.47e-27: 109: 20.65
+	Hs
		1024669 BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31		TRAF3_HUMAN (15-215): 4.28e-31: 121: 20.29
+	Hs
		1036379 BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31		TRAF6_HUMAN (8-235): 8.66e-29: 114: 17.83
+	Hs
		1020642 BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31		TRAF2_HUMAN (15-186): 9.47e-27: 109: 20.65
+	Mm
		1141407 BIRC2_MOUSE (3-497): 5.52e-75: 249: 24.28		TRAF3_MOUSE (15-215): 1.66e-32: 125: 20.29
+	Mm
		761817 BIRC2_MOUSE (3-497): 5.52e-75: 249: 24.28		TRAF2_MOUSE (15-186): 2.58e-25: 104: 20.11
+	Hs
		1024668 BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94		TRAF3_HUMAN (15-215): 4.28e-31: 121: 20.29
+	Mm
		140028 BIRC3_MOUSE (150-342): 6.21e-40: 154: 27.16		TRAF3_MOUSE (15-215): 1.66e-32: 125: 20.29
+	Hs
		1036243 BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94		TRAF6_HUMAN (8-235): 8.66e-29: 114: 17.83
+	Hs
		1036054 BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94		TRIM4_HUMAN (22-162): 4.4e-28: 112: 19.58
+	Hs
		1020641 BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94		TRAF2_HUMAN (15-186): 9.47e-27: 109: 20.65
+	Mm
		140022 BIRC3_MOUSE (150-342): 6.21e-40: 154: 27.16		TRAF2_MOUSE (15-186): 2.58e-25: 104: 20.11
+	Mm
		292206 BIRC6_MOUSE (262-442): 3.14e-27: 118: 19.69		RNF41_MOUSE (25-145): 1.05e-27: 109: 21.43
+	Hs
		1331804 BIRC6_HUMAN (258-442): 3.1e-26: 115: 18.78		RNF41_HUMAN (25-145): 9.57e-28: 109: 21.43
+	Hs
		1165229 LRSM1_HUMAN (330-497): 2.09e-24: 108: 18.45		TRI17_HUMAN (25-167): 3.15e-24: 101: 18.83
+	Dm
		1097107 DIAP2_DROME (14-98): 7.09e-22: 100: 34.12		KCMF1_DROME (84-228): 4.47e-25: 104: 20.13