HitPredict

Interactor 1: XIAP (P98170)
E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
Gene: XIAP

Interactor 2: UB2D4 (Q9Y2X8)
Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4)
Gene: UBE2D4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19549727
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_3
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0070534 - protein K63-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 497 Hs			1 147
+	Hs
		849308 XIAP_HUMAN (1-497): 0: 569: 100.00		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		919707 XIAP_HUMAN (1-497): 0: 569: 100.00		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		895777 XIAP_HUMAN (1-497): 0: 569: 100.00		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		957765 XIAP_HUMAN (1-497): 0: 569: 100.00		UB2E2_HUMAN (4-146): 3.5e-75: 224: 64.34
+	Hs
		851802 XIAP_HUMAN (1-497): 0: 569: 100.00		UB2E1_HUMAN (4-146): 4.67e-73: 218: 64.34
+	Hs
		828984 XIAP_HUMAN (1-497): 0: 569: 100.00		UBE2A_HUMAN (2-144): 4.45e-71: 211: 41.26
+	Hs
		896414 XIAP_HUMAN (1-497): 0: 569: 100.00		UBE2N_HUMAN (4-147): 1.52e-69: 208: 46.53
+	Hs
		849322 BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		919722 BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		895788 BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		927749 BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31		UBE2B_HUMAN (2-144): 2.02e-70: 210: 39.86
+	Hs
		896435 BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31		UBE2N_HUMAN (4-147): 1.52e-69: 208: 46.53
+	Hs
		919818 RSPRY_HUMAN (203-493): 4e-56: 198: 14.71		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		895872 RSPRY_HUMAN (203-493): 4e-56: 198: 14.71		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		849321 BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		919721 BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		895787 BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		849400 BIRC7_HUMAN (14-155): 1.47e-36: 138: 21.83		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		896434 BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94		UBE2N_HUMAN (4-147): 1.52e-69: 208: 46.53
+	Hs
		851864 BIRC7_HUMAN (14-155): 1.47e-36: 138: 21.83		UB2E1_HUMAN (4-146): 4.67e-73: 218: 64.34