HitPredict

Interactor 1: FOXO4 (P98177)
Forkhead box protein O4 (Fork head domain transcription factor AFX1)
Gene: FOXO4

Interactor 2: COP1 (Q8NHY2)
E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2)
Gene: COP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	33101846
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016607 - nuclear speck
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 505 Hs			1 731
+	Hs
		1016215 FOXO1_HUMAN (23-502): 1.08e-55: 199: 34.59		COP1_HUMAN (1-731): 0: 540: 100.00
+	Dm
		1099156 FOXO_DROME (16-501): 3.68e-64: 221: 29.48		CAF1_DROME (512-702): 1.77e-20: 96.7: 14.02
+	Hs
		206780 FOXO3_HUMAN (46-502): 3.73e-64: 222: 35.35		TAF5L_HUMAN (486-667): 2.48e-11: 68.9: 29.57
+	Hs
		877710 FOXA1_HUMAN (4-410): 8.56e-47: 171: 19.86		RBBP4_HUMAN (512-702): 3.22e-20: 96: 14.49
+	Hs
		964169 FOXK2_HUMAN (33-459): 3.11e-45: 170: 18.39		RBBP4_HUMAN (512-702): 3.22e-20: 96: 14.49
+	Hs
		877671 FOXA1_HUMAN (4-410): 8.56e-47: 171: 19.86		WDR5_HUMAN (632-730): 5.38e-16: 81.8: 18.18
+	Hs
		964188 FOXK2_HUMAN (33-459): 3.11e-45: 170: 18.39		RBBP7_HUMAN (476-629): 3.89e-12: 70.9: 29.34
+	Hs
		952817 FOXK1_HUMAN (5-443): 4.01e-43: 164: 19.39		RBBP7_HUMAN (476-629): 3.89e-12: 70.9: 29.34
+	Hs
		1021118 FOXC1_HUMAN (70-237): 5.11e-40: 153: 27.93		RBBP7_HUMAN (476-629): 3.89e-12: 70.9: 29.34
+	Hs
		1021146 FOXC1_HUMAN (70-237): 5.11e-40: 153: 27.93		SNR40_HUMAN (307-447): 5.3e-10: 63.7: 12.67