HitPredict

Interactor 1: TFAM (Q00059)
Transcription factor A, mitochondrial (mtTFA) (Mitochondrial transcription factor 1) (MtTF1) (Transcription factor 6) (TCF-6) (Transcription factor 6-like 2)
Gene: TFAM

Interactor 2: SOX4 (Q06945)
Transcription factor SOX-4
Gene: SOX4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HMG_box~HMG_box, HMG_box~HMG_box_2
Common GO terms	GO:0000976 - transcription cis-regulatory region binding GO:0001666 - response to hypoxia GO:0005634 - nucleus GO:0005739 - mitochondrion GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 246 Hs			1 474
+	Hs
		727727 TFAM_HUMAN (1-246): 1.85e-62: 197: 100.00		SOX5_HUMAN (1-142): 3.98e-39: 152: 36.62
+	Hs
		817923 TFAM_HUMAN (1-246): 1.85e-62: 197: 100.00		SOX2_HUMAN (21-334): 7.94e-41: 150: 25.48
+	Hs
		959010 TFAM_HUMAN (1-246): 1.85e-62: 197: 100.00		CIC_HUMAN (38-288): 5.72e-37: 147: 21.91
+	Hs
		727847 TFAM_HUMAN (1-246): 1.85e-62: 197: 100.00		SOX6_HUMAN (32-234): 1.34e-34: 139: 28.08
+	Hs
		225726 TFAM_HUMAN (1-246): 1.85e-62: 197: 100.00		SOX15_HUMAN (14-239): 6.02e-36: 134: 31.44
+	Hs
		881795 TFAM_HUMAN (1-246): 1.85e-62: 197: 100.00		SOX10_HUMAN (3-380): 3.2e-30: 124: 23.47
+	Hs
		959048 TFAM_HUMAN (1-246): 1.85e-62: 197: 100.00		SOX17_HUMAN (2-281): 6.77e-29: 119: 25.17
+	Dm
		1212959 Q9VUD3_DROME (144-228): 1.27e-24: 103: 20.23		PANG2_DROME (24-409): 3.46e-51: 189: 15.69
+	Hs
		449675 TFAM_HUMAN (1-246): 1.85e-62: 197: 100.00		HMGB1_HUMAN (53-148): 1.47e-13: 71.7: 19.19
+	Dm
		1098030 HMG2_DROME (37-223): 5.62e-35: 130: 20.21		DICH_DROME (17-294): 5.32e-33: 130: 28.78
+	Hs
		727705 SOX6_HUMAN (49-160): 2.17e-25: 106: 12.82		SOX5_HUMAN (1-142): 3.98e-39: 152: 36.62
+	Dm
		114457 M9PCG2_DROME (144-228): 1.41e-24: 103: 20.23		PANG1_DROME (10-409): 6.51e-40: 154: 14.96
+	Hs
		727836 SOX6_HUMAN (49-160): 2.17e-25: 106: 12.82		SOX2_HUMAN (21-334): 7.94e-41: 150: 25.48
+	Mm
		727702 SOX6_MOUSE (49-160): 4.99e-25: 105: 12.82		SOX5_MOUSE (1-142): 1.62e-38: 150: 35.92
+	Hs
		727704 SOX5_HUMAN (49-150): 1.14e-23: 101: 12.75		SOX5_HUMAN (1-142): 3.98e-39: 152: 36.62
+	Hs
		727910 SOX6_HUMAN (49-160): 2.17e-25: 106: 12.82		CIC_HUMAN (38-288): 5.72e-37: 147: 21.91
+	Hs
		133759 SOX5_HUMAN (49-150): 1.14e-23: 101: 12.75		SOX1_HUMAN (20-132): 1.01e-38: 146: 46.90
+	Hs
		727941 SOX6_HUMAN (49-160): 2.17e-25: 106: 12.82		SOX13_HUMAN (7-147): 2.51e-35: 140: 36.88
+	Hs
		727933 SOX6_HUMAN (49-160): 2.17e-25: 106: 12.82		HM20B_HUMAN (11-164): 1.85e-30: 122: 16.88