HitPredict

Interactor 1: TFAM (Q00059)
Transcription factor A, mitochondrial (mtTFA) (Mitochondrial transcription factor 1) (MtTF1) (Transcription factor 6) (TCF-6) (Transcription factor 6-like 2)
Gene: TFAM

Interactor 2: SOX17 (Q9H6I2)
Transcription factor SOX-17
Gene: SOX17

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HMG_box~HMG_box, HMG_box~HMG_box_2
Common GO terms	GO:0000976 - transcription cis-regulatory region binding GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 246 Hs			1 414
+	Hs
		959010 TFAM_HUMAN (1-246): 1.85e-62: 197: 100.00		CIC_HUMAN (10-295): 3.85e-44: 166: 19.66
+	Hs
		727847 TFAM_HUMAN (1-246): 1.85e-62: 197: 100.00		SOX6_HUMAN (46-219): 3.19e-36: 142: 35.36
+	Hs
		727727 TFAM_HUMAN (1-246): 1.85e-62: 197: 100.00		SOX5_HUMAN (39-195): 5.11e-34: 136: 33.33
+	Hs
		958886 TFAM_HUMAN (1-246): 1.85e-62: 197: 100.00		SOX4_HUMAN (34-145): 1.16e-33: 133: 44.54
+	Hs
		817923 TFAM_HUMAN (1-246): 1.85e-62: 197: 100.00		SOX2_HUMAN (36-340): 1.52e-33: 129: 27.33
+	Hs
		881795 TFAM_HUMAN (1-246): 1.85e-62: 197: 100.00		SOX10_HUMAN (33-393): 3.12e-31: 126: 24.81
+	Hs
		225726 TFAM_HUMAN (1-246): 1.85e-62: 197: 100.00		SOX15_HUMAN (53-144): 3.74e-20: 90.5: 55.44
+	Hs
		727910 SOX6_HUMAN (49-160): 2.17e-25: 106: 12.82		CIC_HUMAN (10-295): 3.85e-44: 166: 19.66
+	Hs
		727941 SOX6_HUMAN (49-160): 2.17e-25: 106: 12.82		SOX13_HUMAN (60-202): 5.22e-41: 155: 37.75
+	Dm
		1098030 HMG2_DROME (37-223): 5.62e-35: 130: 20.21		DICH_DROME (14-217): 1.01e-31: 125: 31.37
+	Dm
		1212959 Q9VUD3_DROME (144-228): 1.27e-24: 103: 20.23		PANG2_DROME (14-296): 5.07e-37: 145: 15.77
+	Hs
		727705 SOX6_HUMAN (49-160): 2.17e-25: 106: 12.82		SOX5_HUMAN (39-195): 5.11e-34: 136: 33.33
+	Hs
		727930 SOX6_HUMAN (49-160): 2.17e-25: 106: 12.82		HM20A_HUMAN (1-167): 1.14e-35: 136: 18.61
+	Mm
		727702 SOX6_MOUSE (49-160): 4.99e-25: 105: 12.82		SOX5_MOUSE (39-195): 7.17e-34: 135: 33.33
+	Hs
		727704 SOX5_HUMAN (49-150): 1.14e-23: 101: 12.75		SOX5_HUMAN (39-195): 5.11e-34: 136: 33.33
+	Hs
		727836 SOX6_HUMAN (49-160): 2.17e-25: 106: 12.82		SOX2_HUMAN (36-340): 1.52e-33: 129: 27.33
+	Hs
		133759 SOX5_HUMAN (49-150): 1.14e-23: 101: 12.75		SOX1_HUMAN (63-141): 8.67e-34: 131: 58.23
+	Hs
		727933 SOX6_HUMAN (49-160): 2.17e-25: 106: 12.82		HM20B_HUMAN (1-160): 4.59e-28: 114: 17.28
+	Dm
		114457 M9PCG2_DROME (144-228): 1.41e-24: 103: 20.23		PANG1_DROME (15-296): 1.17e-25: 111: 14.48