HitPredict

Interactor 1: KCC2A (Q00168)
Calcium/calmodulin-dependent protein kinase type II alpha chain (CaM-kinase II alpha chain) (EC 2.7.11.17)
Gene: CaMKII

Interactor 2: KCC2A (Q00168)
Calcium/calmodulin-dependent protein kinase type II alpha chain (CaM-kinase II alpha chain) (EC 2.7.11.17)
Gene: CaMKII

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.78 1.00 0.888

The method score is based on:

Property Details
Experiments 10458610, 8769895, 14699099, 14687552
Identification Methods enzymatic study, protein kinase assay
Interaction Type direct interaction, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains CaMKII_AD~CaMKII_AD, CaMKII_AD~Pkinase, Pkinase~Pkinase
Common GO terms GO:0001818 - negative regulation of cytokine production
GO:0004674 - protein serine/threonine kinase activity
GO:0004683 - calmodulin-dependent protein kinase activity
GO:0005516 - calmodulin binding
GO:0005524 - ATP binding
and 22 others

more...
Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 530
Dm

1 530
+ Hs
+ Hs
+ Hs
+ Mm
+ Rn
+ Hs
+ Hs
+ Hs
+ Gm
+ At
+ At
+ Dm
+ Hs
+ Hs
+ Hs

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Last updated: 15 Jul 2024