HitPredict

Interactor 1: KCC2A (Q00168)
Calcium/calmodulin-dependent protein kinase type II alpha chain (CaM-kinase II alpha chain) (EC 2.7.11.17)
Gene: CaMKII

Interactor 2: KCNAE (Q02280)
Potassium voltage-gated channel protein eag (Ether-a-go-go protein)
Gene: eag

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.830

Property	Details
Experiments	14699099, 30381148
Identification Methods	affinity chromatography technology, x-ray crystallography, enzymatic study, pull down
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	Pkinase~cNMP_binding
Common GO terms	GO:0007611 - learning or memory GO:0007619 - courtship behavior
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 530 Dm			1 1174
+	Dm
		970259 CSKP_DROME (10-304): 4.96e-70: 242: 40.79		KCNAE_DROME (1-1174): 0: 967: 100.00
+	Mm
		292115 KCC2B_MOUSE (1-516): 0: 579: 69.65		HCN1_MOUSE (102-975): 3.56e-166: 517: 16.36
+	Hs
		239979 KCC2G_HUMAN (1-517): 0: 568: 66.79		HCN1_HUMAN (102-934): 4.06e-166: 517: 16.72
+	Hs
		239980 KCC2D_HUMAN (1-518): 0: 565: 72.20		HCN1_HUMAN (102-934): 4.06e-166: 517: 16.72
+	Mm
		292112 KCC2A_MOUSE (1-519): 0: 550: 70.52		HCN1_MOUSE (102-975): 3.56e-166: 517: 16.36
+	Hs
		240280 KCC2A_HUMAN (1-519): 0: 549: 70.52		HCN1_HUMAN (102-934): 4.06e-166: 517: 16.72
+	At
		989492 CDPK1_ARATH (6-450): 7.56e-152: 449: 28.51		CNGC9_ARATH (140-694): 1.4e-180: 549: 18.65
+	At
		989488 CDPK1_ARATH (6-450): 7.56e-152: 449: 28.51		CNG13_ARATH (160-786): 2.28e-175: 534: 16.86
+	At
		989460 CDPK1_ARATH (6-450): 7.56e-152: 449: 28.51		AKT2_ARATH (179-759): 5.37e-164: 508: 20.67
+	Ce
		218171 KCC2D_CAEEL (309-519): 3.8e-67: 232: 40.28		O44164_CAEEL (1-903): 0: 699: 49.17
+	Hs
		239978 KCC2B_HUMAN (273-516): 6.89e-44: 167: 42.62		HCN1_HUMAN (102-934): 4.06e-166: 517: 16.72