HitPredict

Interactor 1: CDK3 (Q00526)
Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3)
Gene: CDK3

Interactor 2: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FKBP_C~Pkinase
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 305 Hs			1 457
+	Hs
		625378 CDK2_HUMAN (1-292): 1.87e-148: 420: 76.71		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		414904 CDK1_HUMAN (1-290): 1.16e-137: 392: 65.98		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		960281 CDK5_HUMAN (1-292): 8.97e-133: 380: 60.75		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		841189 CDK7_HUMAN (3-296): 2.86e-124: 360: 45.64		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		960271 CDK5_HUMAN (1-292): 8.97e-133: 380: 60.75		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		684635 CDK3_HUMAN (1-305): 1.8e-151: 427: 100.00		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		414775 CDK1_HUMAN (1-290): 1.16e-137: 392: 65.98		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		684636 CDK5_HUMAN (1-292): 8.97e-133: 380: 60.75		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62