HitPredict

Interactor 1: CDKL1 (Q00532)
Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Protein kinase p42 KKIALRE) (Serine/threonine-protein kinase KKIALRE)
Gene: CDKL1

Interactor 2: H90B4 (Q58FF6)
Putative heat shock protein HSP 90-beta 4
Gene: HSP90AB4P

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.712

Property	Details
Experiments	28514442, 33961781
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 357 Hs			1 505
+	Hs
		437908 CDK2_HUMAN (1-293): 6.21e-155: 438: 38.44		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		431549 CDK2_HUMAN (1-293): 6.21e-155: 438: 38.44		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		438075 CDK3_HUMAN (1-306): 1.19e-147: 420: 40.39		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		431741 CDK3_HUMAN (1-306): 1.19e-147: 420: 40.39		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		438250 CDKL4_HUMAN (1-336): 4.57e-140: 404: 63.85		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		438077 CDK5_HUMAN (1-293): 1.2e-137: 394: 39.12		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		960099 CDK3_HUMAN (1-306): 1.19e-147: 420: 40.39		H90B4_HUMAN (1-505): 0: 644: 100.00
+	Hs
		431937 CDKL4_HUMAN (1-336): 4.57e-140: 404: 63.85		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		414683 CDK1_HUMAN (1-292): 2.16e-138: 396: 39.80		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		431743 CDK5_HUMAN (1-293): 1.2e-137: 394: 39.12		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		1123409 CDKL4_HUMAN (1-336): 4.57e-140: 404: 63.85		H90B4_HUMAN (1-505): 0: 644: 100.00
+	Hs
		432124 CDKL2_HUMAN (1-344): 2.24e-133: 391: 50.57		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		538107 CDK2_HUMAN (1-293): 6.21e-155: 438: 38.44		ENPL_HUMAN (1-504): 0: 597: 35.70
+	Mm
		513676 CDKL5_MOUSE (1-310): 1.89e-88: 286: 46.47		HS90B_MOUSE (1-504): 0: 673: 70.11
+	Hs
		438004 CDK7_HUMAN (2-289): 7.01e-63: 206: 39.87		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		431662 CDK7_HUMAN (2-289): 7.01e-63: 206: 39.87		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		841223 CDK7_HUMAN (2-289): 7.01e-63: 206: 39.87		H90B4_HUMAN (1-505): 0: 644: 100.00
+	Hs
		960137 CDKL1_HUMAN (1-357): 1.14e-143: 412: 100.00		H90B3_HUMAN (1-504): 3.09e-143: 426: 58.87
+	Hs
		1123450 CDKL4_HUMAN (1-336): 4.57e-140: 404: 63.85		H90B3_HUMAN (1-504): 3.09e-143: 426: 58.87
+	Hs
		841224 CDK7_HUMAN (2-289): 7.01e-63: 206: 39.87		H90B3_HUMAN (1-504): 3.09e-143: 426: 58.87