HitPredict

Interactor 1: CDK6 (Q00534)
Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE)
Gene: CDK6

Interactor 2: H11 (Q02539)
Histone H1.1 (Histone H1a)
Gene: H1-1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	16878158, 9885575
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 326 Hs			1 215
+	Rn
		413197 Q6P751_RAT (10-311): 1.18e-145: 414: 47.06		H1T_RAT (1-213): 4.75e-37: 130: 48.37
+	Hs
		559328 CDK2_HUMAN (10-311): 3.22e-146: 415: 47.39		H13_HUMAN (1-169): 5.79e-27: 104: 55.03
+	Rn
		88903 Q6P751_RAT (10-311): 1.18e-145: 414: 47.06		H11_RAT (1-123): 9.41e-24: 95.9: 77.24
+	Hs
		558990 CDK2_HUMAN (10-311): 3.22e-146: 415: 47.39		H15_HUMAN (1-118): 1.18e-22: 93.2: 72.88
+	Hs
		625377 CDK2_HUMAN (10-311): 3.22e-146: 415: 47.39		H11_HUMAN (1-199): 7.29e-21: 88.2: 100.00
+	Mm
		794656 CDK2_MOUSE (10-311): 4.07e-137: 394: 40.68		H15_MOUSE (1-199): 6.17e-23: 94: 56.59
+	Mm
		794650 CDK6_MOUSE (1-326): 4.71e-143: 408: 96.32		H11_MOUSE (1-124): 1.61e-17: 79.4: 79.84
+	Hs
		414717 CDK1_HUMAN (10-305): 5.07e-129: 371: 45.18		H13_HUMAN (1-169): 5.79e-27: 104: 55.03
+	Mm
		550489 CDK2_MOUSE (10-311): 4.07e-137: 394: 40.68		H12_MOUSE (33-118): 1.42e-17: 79.4: 80.23
+	Mm
		794643 CDK2_MOUSE (10-311): 4.07e-137: 394: 40.68		H11_MOUSE (1-124): 1.61e-17: 79.4: 79.84
+	Mm
		673226 CDK4_MOUSE (9-305): 4.78e-132: 379: 68.67		H15_MOUSE (1-199): 6.17e-23: 94: 56.59
+	Hs
		515324 CDK4_HUMAN (9-304): 4e-126: 364: 70.23		H13_HUMAN (1-169): 5.79e-27: 104: 55.03
+	Rn
		88899 CDK1_RAT (10-305): 4.07e-129: 372: 45.18		H11_RAT (1-123): 9.41e-24: 95.9: 77.24
+	Hs
		414716 CDK1_HUMAN (10-305): 5.07e-129: 371: 45.18		H15_HUMAN (1-118): 1.18e-22: 93.2: 72.88
+	Hs
		414874 CDK1_HUMAN (10-305): 5.07e-129: 371: 45.18		H11_HUMAN (1-199): 7.29e-21: 88.2: 100.00
+	Mm
		550487 CDK4_MOUSE (9-305): 4.78e-132: 379: 68.67		H12_MOUSE (33-118): 1.42e-17: 79.4: 80.23
+	Mm
		673225 CDK4_MOUSE (9-305): 4.78e-132: 379: 68.67		H11_MOUSE (1-124): 1.61e-17: 79.4: 79.84
+	Hs
		515403 CDK4_HUMAN (9-304): 4e-126: 364: 70.23		H11_HUMAN (1-199): 7.29e-21: 88.2: 100.00
+	Mm
		509461 CDK1_MOUSE (10-305): 2.82e-128: 369: 45.18		H12_MOUSE (33-118): 1.42e-17: 79.4: 80.23
+	Mm
		509472 CDK1_MOUSE (10-305): 2.82e-128: 369: 45.18		H11_MOUSE (1-124): 1.61e-17: 79.4: 79.84