HitPredict

Interactor 1: CDK5 (Q00535)
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
Gene: CDK5

Interactor 2: H11 (Q02539)
Histone H1.1 (Histone H1a)
Gene: H1-1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	10604467, 16029324, 29651006, 34349018
Identification Methods	enzymatic study, cross-linking study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 292 Hs			1 215
+	Rn
		413197 Q6P751_RAT (1-292): 2.27e-143: 406: 59.73		H1T_RAT (1-213): 4.75e-37: 130: 48.37
+	Hs
		559328 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		H13_HUMAN (1-169): 5.79e-27: 104: 55.03
+	Rn
		88903 Q6P751_RAT (1-292): 2.27e-143: 406: 59.73		H11_RAT (1-123): 9.41e-24: 95.9: 77.24
+	Hs
		558990 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		H15_HUMAN (1-118): 1.18e-22: 93.2: 72.88
+	Hs
		625377 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		H11_HUMAN (1-199): 7.29e-21: 88.2: 100.00
+	Hs
		559654 CDK5_HUMAN (1-292): 6.09e-139: 395: 100.00		H12_HUMAN (32-175): 4.83e-23: 94: 54.86
+	Hs
		559065 CDK5_HUMAN (1-292): 6.09e-139: 395: 100.00		H15_HUMAN (1-118): 1.18e-22: 93.2: 72.88
+	Hs
		414717 CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01		H13_HUMAN (1-169): 5.79e-27: 104: 55.03
+	Hs
		489003 CDK5_HUMAN (1-292): 6.09e-139: 395: 100.00		H14_HUMAN (1-149): 9.6e-22: 90.5: 63.76
+	Mm
		794656 CDK2_MOUSE (1-292): 7.36e-136: 389: 51.77		H15_MOUSE (1-199): 6.17e-23: 94: 56.59
+	Rn
		88899 CDK1_RAT (1-289): 2.13e-134: 383: 56.70		H11_RAT (1-123): 9.41e-24: 95.9: 77.24
+	Hs
		414716 CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01		H15_HUMAN (1-118): 1.18e-22: 93.2: 72.88
+	Mm
		794639 CDK5_MOUSE (1-292): 9.13e-139: 394: 99.66		H11_MOUSE (1-124): 1.61e-17: 79.4: 79.84
+	Hs
		414874 CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01		H11_HUMAN (1-199): 7.29e-21: 88.2: 100.00
+	Hs
		559352 CDK7_HUMAN (2-292): 2.63e-127: 367: 45.24		H13_HUMAN (1-169): 5.79e-27: 104: 55.03
+	Mm
		550489 CDK2_MOUSE (1-292): 7.36e-136: 389: 51.77		H12_MOUSE (33-118): 1.42e-17: 79.4: 80.23
+	Mm
		794643 CDK2_MOUSE (1-292): 7.36e-136: 389: 51.77		H11_MOUSE (1-124): 1.61e-17: 79.4: 79.84
+	Mm
		509461 CDK1_MOUSE (1-289): 2.16e-133: 381: 56.70		H12_MOUSE (33-118): 1.42e-17: 79.4: 80.23
+	Mm
		509472 CDK1_MOUSE (1-289): 2.16e-133: 381: 56.70		H11_MOUSE (1-124): 1.61e-17: 79.4: 79.84
+	Hs
		488949 CDK7_HUMAN (2-292): 2.63e-127: 367: 45.24		H14_HUMAN (1-149): 9.6e-22: 90.5: 63.76