HitPredict

Interactor 1: CDK5 (Q00535)
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
Gene: CDK5

Interactor 2: LARP7 (Q4G0J3)
La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S)
Gene: LARP7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29845934
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 292 Hs			1 582
+	Hs
		625477 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		960098 CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		414946 CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		960440 CDK17_HUMAN (1-291): 3.52e-121: 358: 55.82		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		960373 CDK16_HUMAN (1-286): 1.11e-115: 343: 57.99		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		989681 CDK18_HUMAN (1-286): 1.22e-108: 325: 56.94		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		300640 CDK14_HUMAN (4-291): 1.17e-103: 311: 54.61		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		403088 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		LA_HUMAN (24-365): 5.96e-44: 163: 18.83
+	Hs
		516362 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29
+	At
		1103363 CKB12_ARATH (1-289): 1.61e-123: 356: 50.97		LRP1A_ARATH (10-367): 4.77e-56: 204: 16.85
+	Sc
		565522 PHO85_YEAST (3-290): 5.6e-128: 368: 55.03		LHP1_YEAST (7-270): 1.34e-45: 163: 22.74
+	Hs
		841320 CDK7_HUMAN (2-292): 2.63e-127: 367: 45.24		PABP3_HUMAN (1-333): 6.27e-42: 162: 10.11
+	Sc
		339316 CDK1_YEAST (1-288): 1.39e-123: 356: 55.44		PABP_YEAST (9-243): 8.44e-33: 134: 13.47
+	Hs
		841335 CDK7_HUMAN (2-292): 2.63e-127: 367: 45.24		RBM28_HUMAN (40-343): 2.97e-23: 106: 13.84
+	Dm
		582590 CDK2_DROME (1-289): 8.92e-127: 365: 49.48		SXL_DROME (59-259): 1.13e-24: 107: 20.29
+	Hs
		989704 CDK18_HUMAN (1-286): 1.22e-108: 325: 56.94		LAR4B_HUMAN (2-216): 8.48e-36: 145: 17.02
+	Hs
		414931 CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50
+	At
		1321248 CDKD2_ARATH (1-292): 2.99e-129: 372: 46.58		PABP8_ARATH (2-127): 5.76e-15: 80: 11.91
+	Hs
		841210 CDK7_HUMAN (2-292): 2.63e-127: 367: 45.24		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50
+	Dm
		114975 M9PE01_DROME (2-289): 6.31e-103: 312: 53.77		LARP_DROME (38-120): 1.58e-13: 76.1: 35.23