HitPredict

Interactor 1: CDK5 (Q00535)
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
Gene: CDK5

Interactor 2: TRI59 (Q8IWR1)
Tripartite motif-containing protein 59 (EC 2.3.2.27) (RING finger protein 104) (Tumor suppressor TSBF-1)
Gene: TRIM59

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.50	0.528

Property	Details
Experiments	31488827
Identification Methods	affinity chromatography technology, pull down, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 292 Hs			1 403
+	Hs
		584875 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		RO52_HUMAN (1-352): 8.74e-78: 249: 16.15
+	Hs
		584906 CDK7_HUMAN (2-292): 2.63e-127: 367: 45.24		RO52_HUMAN (1-352): 8.74e-78: 249: 16.15
+	Mm
		829602 CDK5_MOUSE (1-292): 9.13e-139: 394: 99.66		TRI72_MOUSE (4-339): 2.41e-64: 215: 23.38
+	Hs
		960118 CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30		TRI55_HUMAN (1-267): 8.15e-61: 207: 23.96
+	Mm
		509482 CDK1_MOUSE (1-289): 2.16e-133: 381: 56.70		TRI72_MOUSE (4-339): 2.41e-64: 215: 23.38
+	Hs
		960115 CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30		TRI63_HUMAN (1-269): 1.62e-57: 193: 25.27
+	Hs
		841308 CDK7_HUMAN (2-292): 2.63e-127: 367: 45.24		TRI51_HUMAN (1-288): 1.79e-55: 191: 20.49
+	Hs
		536798 CDK18_HUMAN (1-286): 1.22e-108: 325: 56.94		TRI27_HUMAN (2-353): 5.58e-67: 222: 15.63
+	Hs
		989694 CDK18_HUMAN (1-286): 1.22e-108: 325: 56.94		TRI50_HUMAN (1-352): 5.39e-61: 206: 19.77
+	Hs
		989721 CDK18_HUMAN (1-286): 1.22e-108: 325: 56.94		TRI54_HUMAN (1-323): 5.54e-58: 195: 22.65
+	Hs
		989730 CDK18_HUMAN (1-286): 1.22e-108: 325: 56.94		TRIM1_HUMAN (1-286): 9.68e-15: 78.2: 22.51