HitPredict

Interactor 1: CDK5 (Q00535)
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
Gene: CDK5

Interactor 2: FYV1 (Q9Y2I7)
1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1)
Gene: PIKFYVE

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	28637746
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0005829 - cytosol GO:0106310 - protein serine kinase activity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 292 Hs			1 2098
+	Hs
		625220 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		TCPE_HUMAN (449-995): 6.65e-167: 524: 14.80
+	Hs
		821173 CDK5_HUMAN (1-292): 6.09e-139: 395: 100.00		TCPE_HUMAN (449-995): 6.65e-167: 524: 14.80
+	Hs
		573132 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		TCPA_HUMAN (470-1004): 9.34e-162: 511: 12.77
+	Hs
		414817 CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01		TCPE_HUMAN (449-995): 6.65e-167: 524: 14.80
+	Hs
		625228 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		TCPG_HUMAN (459-1010): 6.42e-159: 502: 17.35
+	Hs
		573225 CDK5_HUMAN (1-292): 6.09e-139: 395: 100.00		TCPA_HUMAN (470-1004): 9.34e-162: 511: 12.77
+	Hs
		826623 CDK5_HUMAN (1-292): 6.09e-139: 395: 100.00		TCPG_HUMAN (459-1010): 6.42e-159: 502: 17.35
+	Hs
		414725 CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01		TCPA_HUMAN (470-1004): 9.34e-162: 511: 12.77
+	Hs
		625246 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		TCPD_HUMAN (449-990): 1.17e-145: 465: 16.19
+	Hs
		843162 CDK5_HUMAN (1-292): 6.09e-139: 395: 100.00		TCPD_HUMAN (449-990): 1.17e-145: 465: 16.19
+	Hs
		414827 CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01		TCPD_HUMAN (449-990): 1.17e-145: 465: 16.19
+	Hs
		821179 CDK18_HUMAN (1-286): 1.22e-108: 325: 56.94		TCPE_HUMAN (449-995): 6.65e-167: 524: 14.80
+	Hs
		573231 CDK18_HUMAN (1-286): 1.22e-108: 325: 56.94		TCPA_HUMAN (470-1004): 9.34e-162: 511: 12.77
+	Hs
		826627 CDK18_HUMAN (1-286): 1.22e-108: 325: 56.94		TCPG_HUMAN (459-1010): 6.42e-159: 502: 17.35
+	Hs
		843169 CDK18_HUMAN (1-286): 1.22e-108: 325: 56.94		TCPD_HUMAN (449-990): 1.17e-145: 465: 16.19
+	Sc
		339699 CDK1_YEAST (1-288): 1.39e-123: 356: 55.44		TCPH_YEAST (591-941): 6.81e-70: 248: 19.95
+	Sc
		565532 PHO85_YEAST (3-290): 5.6e-128: 368: 55.03		FAB1_YEAST (152-231): 3.15e-20: 101: 45.00
+	Sc
		339563 CDK1_YEAST (1-288): 1.39e-123: 356: 55.44		FAB1_YEAST (152-231): 3.15e-20: 101: 45.00