HitPredict

Interactor 1: CDK16 (Q00536)
Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1)
Gene: CDK16

Interactor 2: CCNI (Q14094)
Cyclin-I
Gene: CCNI

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	22184064
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cyclin_N~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0007283 - spermatogenesis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 496 Hs			1 377
+	Hs
		625423 CDK2_HUMAN (162-456): 6.05e-145: 418: 53.54		CCNI_HUMAN (1-377): 6.48e-115: 340: 100.00
+	Hs
		960093 CDK3_HUMAN (162-453): 2.39e-142: 412: 53.06		CCNI_HUMAN (1-377): 6.48e-115: 340: 100.00
+	Hs
		303844 CDK17_HUMAN (4-490): 2.31e-154: 451: 68.67		CCNB2_HUMAN (5-287): 4e-77: 244: 15.44
+	Hs
		625350 CDK2_HUMAN (162-456): 6.05e-145: 418: 53.54		CCNA1_HUMAN (9-275): 1.52e-84: 266: 15.67
+	Hs
		538471 CDK2_HUMAN (162-456): 6.05e-145: 418: 53.54		CCNB1_HUMAN (5-272): 1.51e-81: 257: 18.52
+	Hs
		538521 CDK3_HUMAN (162-453): 2.39e-142: 412: 53.06		CCNB1_HUMAN (5-272): 1.51e-81: 257: 18.52
+	Hs
		303829 CDK2_HUMAN (162-456): 6.05e-145: 418: 53.54		CCNB2_HUMAN (5-287): 4e-77: 244: 15.44
+	At
		1059425 CDKD1_ARATH (156-494): 6.45e-136: 399: 35.53		CCA22_ARATH (5-281): 5.07e-83: 261: 17.33
+	At
		1104377 CDKD1_ARATH (156-494): 6.45e-136: 399: 35.53		CCA23_ARATH (5-279): 7.1e-83: 261: 17.09
+	Hs
		590125 CDK2_HUMAN (162-456): 6.05e-145: 418: 53.54		CCNA2_HUMAN (10-271): 4.71e-74: 238: 17.49
+	Hs
		590162 CDK3_HUMAN (162-453): 2.39e-142: 412: 53.06		CCNA2_HUMAN (10-271): 4.71e-74: 238: 17.49
+	Hs
		625253 CDK2_HUMAN (162-456): 6.05e-145: 418: 53.54		CCNG1_HUMAN (8-253): 5.28e-71: 225: 28.06
+	Hs
		624539 CDK2_HUMAN (162-456): 6.05e-145: 418: 53.54		CCNE1_HUMAN (3-298): 7.23e-67: 218: 19.06
+	Rn
		981205 Q6P751_RAT (162-456): 5.42e-145: 418: 53.87		CCND2_RAT (15-271): 2.71e-66: 213: 21.64
+	Hs
		624573 CDK3_HUMAN (162-453): 2.39e-142: 412: 53.06		CCNE1_HUMAN (3-298): 7.23e-67: 218: 19.06
+	Rn
		70081 Q6P751_RAT (162-456): 5.42e-145: 418: 53.87		B1WC54_RAT (17-256): 1.65e-57: 194: 24.51
+	Xl
		193809 CDK2_XENLA (162-456): 1.46e-144: 417: 53.20		CCNE3_XENLA (25-208): 3.63e-54: 185: 27.03
+	Hs
		331629 CDK2_HUMAN (162-456): 6.05e-145: 418: 53.54		CCNE2_HUMAN (37-207): 9.11e-53: 181: 30.64
+	Hs
		625523 CDK2_HUMAN (162-456): 6.05e-145: 418: 53.54		Q8WUE3_HUMAN (37-207): 1.91e-52: 180: 30.64
+	Hs
		331637 CDK3_HUMAN (162-453): 2.39e-142: 412: 53.06		CCNE2_HUMAN (37-207): 9.11e-53: 181: 30.64