HitPredict

Interactor 1: CDK16 (Q00536)
Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1)
Gene: CDK16

Interactor 2: CCYL1 (Q8N7R7)
Cyclin-Y-like protein 1
Gene: CCNYL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.968

Property	Details
Experiments	25852190, 26186194, 26496610, 28514442, 33961781, 32707033, 22184064
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, two hybrid, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cyclin_N~Pkinase
Common GO terms	GO:0005886 - plasma membrane GO:0007283 - spermatogenesis
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 496 Hs			1 359
+	Mm
		88307 CDK16_MOUSE (1-496): 2.87e-177: 508: 97.58		CCYL1_MOUSE (10-359): 0: 574: 92.39
+	Hs
		960443 CDK17_HUMAN (4-490): 2.31e-154: 451: 68.67		CCYL1_HUMAN (1-359): 0: 612: 100.00
+	Hs
		960390 CDK16_HUMAN (1-496): 2.61e-178: 511: 100.00		CCNY_HUMAN (1-359): 0: 550: 70.25
+	Mm
		980962 CDK16_MOUSE (1-496): 2.87e-177: 508: 97.58		CCNY_MOUSE (1-359): 0: 547: 69.97
+	Hs
		300642 CDK14_HUMAN (159-474): 3.24e-130: 387: 60.19		CCNY_HUMAN (1-359): 0: 550: 70.25
+	Mm
		192818 CDK14_MOUSE (159-474): 1.75e-130: 388: 60.19		CCNY_MOUSE (1-359): 0: 547: 69.97
+	Dm
		1180794 Q7KM03_DROME (4-479): 4.35e-136: 404: 43.81		Q9VKF0_DROME (1-359): 0: 515: 51.34
+	Dm
		1277023 Q94888_DROME (4-479): 1.48e-135: 402: 44.47		Q9VKF0_DROME (1-359): 0: 515: 51.34
+	Ce
		712415 CDK17_CAEEL (17-473): 3.61e-136: 409: 54.80		CCNY_CAEEL (1-359): 0: 508: 49.60