HitPredict

Interactor 1: CLH1 (Q00610)
Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17)
Gene: CLTC

Interactor 2: AP1B1 (Q10567)
AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit)
Gene: AP1B1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9280305
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Alpha_adaptinC2~Clathrin
Common GO terms	GO:0005829 - cytosol GO:0006886 - intracellular protein transport GO:0019901 - protein kinase binding GO:0032588 - trans-Golgi network membrane
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1675 Hs			1 949
+	Hs
		925852 CLH1_HUMAN (1-1675): 0: 3132: 100.00		AP2B1_HUMAN (1-949): 0: 944: 81.45
+	Rn
		509763 CLH1_RAT (1-1675): 0: 3123: 99.76		AP2B1_RAT (1-949): 0: 944: 81.45
+	Hs
		321529 CLH1_HUMAN (1-1675): 0: 3132: 100.00		AP2A1_HUMAN (12-943): 0: 677: 18.58
+	Mm
		567504 CLH1_MOUSE (1-1675): 0: 3131: 99.88		AP2A1_MOUSE (12-943): 0: 673: 17.97
+	Hs
		302138 CLH1_HUMAN (1-1675): 0: 3132: 100.00		AP2A2_HUMAN (12-945): 0: 625: 18.33
+	Hs
		212619 CLH1_HUMAN (1-1675): 0: 3132: 100.00		AP1G1_HUMAN (12-822): 0: 556: 17.29
+	Hs
		960775 CLH1_HUMAN (1-1675): 0: 3132: 100.00		AP3B2_HUMAN (6-627): 2.76e-180: 553: 27.47
+	At
		1012804 CLAH1_ARATH (6-1636): 0: 2638: 56.38		APBLB_ARATH (3-948): 0: 774: 56.69
+	Dm
		669566 CLH_DROME (1-1663): 0: 2911: 80.17		COPB_DROME (17-457): 1.21e-14: 80.5: 21.64
+	Sc
		604384 CLH_YEAST (5-1648): 0: 2443: 49.79		AP1B1_YEAST (12-705): 9.09e-171: 517: 36.31
+	Sc
		604359 CLH_YEAST (5-1648): 0: 2443: 49.79		AP2B_YEAST (1-579): 3.65e-82: 282: 31.95