HitPredict

Interactor 1: CLH1 (Q00610)
Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17)
Gene: CLTC

Interactor 2: TNK1 (Q13470)
Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1)
Gene: TNK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016020 - membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1675 Hs			1 666
+	Hs
		383746 CLH1_HUMAN (1-1675): 0: 3132: 100.00		ERBB2_HUMAN (65-631): 7.95e-122: 393: 22.82
+	Hs
		665391 CLH1_HUMAN (1-1675): 0: 3132: 100.00		EPHA3_HUMAN (83-408): 1.77e-119: 381: 31.50
+	Hs
		412135 CLH1_HUMAN (1-1675): 0: 3132: 100.00		FYN_HUMAN (3-393): 4.79e-122: 375: 23.79
+	Hs
		522915 CLH1_HUMAN (1-1675): 0: 3132: 100.00		SRC_HUMAN (2-393): 5.17e-122: 375: 25.51
+	Hs
		665213 CLH1_HUMAN (1-1675): 0: 3132: 100.00		EPHA2_HUMAN (64-447): 1.01e-108: 352: 27.74
+	Hs
		338288 CLH1_HUMAN (1-1675): 0: 3132: 100.00		EGFR_HUMAN (89-373): 4.38e-46: 178: 36.59
+	Hs
		960790 CLH1_HUMAN (1-1675): 0: 3132: 100.00		FAK2_HUMAN (92-373): 3.64e-45: 175: 36.88
+	Mm
		222849 CLH1_MOUSE (1-1675): 0: 3131: 99.88		ACK1_MOUSE (391-664): 9.23e-26: 115: 20.50
+	Hs
		960761 CLH1_HUMAN (1-1675): 0: 3132: 100.00		ACK1_HUMAN (391-664): 6.16e-22: 103: 20.79
+	Hs
		338174 CLH2_HUMAN (1-1634): 0: 2869: 85.01		EGFR_HUMAN (89-373): 4.38e-46: 178: 36.59