HitPredict

Interactor 1: CLH1 (Q00610)
Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17)
Gene: CLTC

Interactor 2: AP2M1 (Q96CW1)
AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein)
Gene: AP2M1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

The method score is based on:

Property	Details
Experiments	26496610, 19380743, 34964704
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006886 - intracellular protein transport GO:0030669 - clathrin-coated endocytic vesicle membrane GO:0031623 - receptor internalization and 7 others more... GO:0036020 - endolysosome membrane GO:0045334 - clathrin-coated endocytic vesicle GO:0050750 - low-density lipoprotein particle receptor binding GO:0070062 - extracellular exosome GO:0072583 - clathrin-dependent endocytosis GO:0097718 - disordered domain specific binding GO:1903077 - negative regulation of protein localization to plasma membrane
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	1675
Hs

1	435

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024